{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:27:25Z","timestamp":1789997245481,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T00:00:00Z","timestamp":1557014400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2019,5,5]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To report our experience in a compassionate use program for complex perianal fistula. <jats:italic>Methods<\/jats:italic>. Under controlled circumstances and approved by European and Spanish laws, a compassionate use program allows the use of stem cell therapy for patients with nonhealing diseases, mostly complex fistula-in-ano, who do not meet criteria to be included in a clinical trial. Candidates had previously undergone multiple surgical interventions that had failed. The intervention consisted of surgery (with closure of the internal opening or a surgical flap performance), followed by stem cell injection. Three types of cells were used for implant: stromal vascular fraction, autologous expanded adipose-derived, or allogenic adipose-derived stem cells. Healing was evaluated at 6<jats:sup>th<\/jats:sup> month follow-up. Outcome was classified as partial response or healing. Relapse was evaluated 1 year later. Maximum follow-up period was 48 months. <jats:italic>Results<\/jats:italic>. 45 patients (24 male) were included; the mean age was 45 years, which ranged from 24 to 69 years. Since some of them received repeated doses, 52 cases were considered (42 fistula-in-ano, 7 rectovaginal fistulas, 1 urethrorectal fistula, 1 sacral fistula, and 1 hidradenitis suppurativa). Regarding fistula-in-ano, there were 18 Crohn\u2019s-associated and 24 cryptoglandular. 49 cases (94.2%) showed partial response starting 6.5 weeks of follow-up. 24 cases (46.2%) healed in a mean time of 5.5 months. A year later, all patients cured remained healed. No adverse effects related to stem cell therapy were reported. <jats:italic>Conclusion<\/jats:italic>. Stem cells are safe and useful for treating anal fistulae. Healing can be achieved in severe cases.<\/jats:p>","DOI":"10.1155\/2019\/6132340","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T11:15:45Z","timestamp":1557141345000},"page":"1-6","source":"Crossref","is-referenced-by-count":47,"title":["Stem Cell Therapy: A Compassionate Use Program in Perianal Fistula"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-4518","authenticated-orcid":true,"given":"M. D.","family":"Herreros","sequence":"first","affiliation":[{"name":"Department of Surgery, University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Garcia-Olmo","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"New Therapy Laboratory, Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"Surgery Department, Universidad Autonoma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Guadalajara","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"Surgery Department, Universidad Autonoma de Madrid, Madrid, Spain"},{"name":"Department of Surgery, Hospital General de Villalba, Collado Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Georgiev-Hristov","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital General de Villalba, Collado Villalba, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Brandariz","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garcia-Arranz","sequence":"additional","affiliation":[{"name":"New Therapy Laboratory, Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"},{"name":"Surgery Department, Universidad Autonoma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"219","volume":"73","year":"1984","journal-title":"Annales Chirurgiae et Gynaecologiae"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237422"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0055-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630102"},{"issue":"4","key":"6","first-page":"442","volume":"12","year":"2010","journal-title":"Current Opinion in Molecular Therapeutics"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e328330e9be"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.11.041"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/01.SAP.0000029661.38066.15"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-31265-X_4"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.70.300"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.07.010"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05409.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0105"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1080\/14653240310004539"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03573.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0052-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181973487"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318255364a"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31203-X"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.01.009"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-3895-6"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1350-1"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.020"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1296355"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000154"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9354-9"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2019\/6132340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2019\/6132340.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2019\/6132340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T11:15:47Z","timestamp":1557141347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/sci\/2019\/6132340\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,5]]},"references-count":28,"alternative-id":["6132340","6132340"],"URL":"https:\/\/doi.org\/10.1155\/2019\/6132340","relation":{},"ISSN":["1687-966X","1687-9678"],"issn-type":[{"value":"1687-966X","type":"print"},{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,5]]}}}