{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:31:04Z","timestamp":1790245864161,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,11,19]]},"abstract":"<jats:p><jats:italic>Berberis vulgaris<\/jats:italic> is a well-known herb in Iran that is widely used as a medicinal plant and a food additive. The aim of this study was to investigate the anti-inflammatory and immunomodulatory effects of Barberry and its main compounds. This narrative review was conducted by searching keywords such as <jats:italic>B<\/jats:italic>. <jats:italic>vulgaris<\/jats:italic>, Barberry, immunomodulatory, anti-inflammatory, medicinal herbs, plants, and extract, separately or combined in various databases, such as Web of Sciences, PubMed, and Scopus. According to the inclusion and exclusion criteria, just English language articles, which reported effective whole plants or herbal compounds, were included. 21 articles were reviewed in this study. In the <jats:italic>in vivo<\/jats:italic> models (mice, rats, and human cells) and in the <jats:italic>in vitro<\/jats:italic> models (some organ cells such as the spleen, kidney, blood, and brain), <jats:italic>B<\/jats:italic>. <jats:italic>vulgaris<\/jats:italic> and its main components showed anti-inflammatory effects in both models. The main mechanisms were the shift of cell immune response to Th2, T reg induction, inhibition of inflammatory cytokines (IL-1, TNF, and IFN-<jats:italic>\u03b3<\/jats:italic>), and stimulation of IL-4 and IL-10. The induction of apoptosis in APCs and other effector cells was another important mechanism.<\/jats:p>","DOI":"10.1155\/2019\/6183965","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T18:30:59Z","timestamp":1574188259000},"page":"1-10","source":"Crossref","is-referenced-by-count":46,"title":["Anti-Inflammatory and Immunomodulatory Effects of Barberry (<i>Berberis vulgaris<\/i>) and Its Main Compounds"],"prefix":"10.1155","volume":"2019","author":[{"given":"Rasool Nasiri","family":"Kalmarzi","sequence":"first","affiliation":[{"name":"Lung Diseases & Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Nima","family":"Naleini","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damoon","family":"Ashtary-Larky","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-5241","authenticated-orcid":true,"given":"Ilaria","family":"Peluso","sequence":"additional","affiliation":[{"name":"Council for Agricultural Research and Economics (CREA), Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Jouybari","sequence":"additional","affiliation":[{"name":"Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Rafi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Ghorat","sequence":"additional","affiliation":[{"name":"Traditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishteman","family":"Heidari","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Sharifian","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9010-2518","authenticated-orcid":true,"given":"Jalal","family":"Mardaneh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine & Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Aiello","sequence":"additional","affiliation":[{"name":"Council for Agricultural Research and Economics (CREA), Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy"},{"name":"Department of Physiology and Pharmacology \u201cV. 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