{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:53:55Z","timestamp":1792029235907,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2019,3,12]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Postoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery.<jats:italic> Methods<\/jats:italic>. We evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Both urinary kidney injury molecule 1 and serum creatinine were evaluated before operation and 3hs and 24hs after operation. Acute kidney injury was diagnosed according to Kidney Disease: Improving Global Outcomes, 2012 guidelines.<jats:italic> Results<\/jats:italic>. In this study, 27 patients developed acute kidney injury. The three hour-post-surgery urinary kidney injury molecule 1 was significantly higher in the acute kidney injury group (P&lt;0.015) and, at the same time, we did not find any significant difference in the serum creatinine levels between the two groups.<jats:italic> Conclusion<\/jats:italic>. Although serum creatinine is still the gold standard for diagnosis of acute kidney injury searching for other new markers is mandatory. Urinary kidney injury molecule 1 can be used as simple noninvasive and specific biomarker for early diagnosis of acute kidney injury.<\/jats:p>","DOI":"10.1155\/2019\/6265307","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T19:31:07Z","timestamp":1552419067000},"page":"1-6","source":"Crossref","is-referenced-by-count":40,"title":["Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients"],"prefix":"10.1155","volume":"2019","author":[{"given":"Nora A.","family":"Khreba","sequence":"first","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-2777","authenticated-orcid":true,"given":"Mostafa","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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