{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:09:12Z","timestamp":1791925752120,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,12,6]]},"abstract":"<jats:p>\n                    Myricetin (Myr) is a common plant-derived polyphenol and is well recognized for its multiple activities including antioxidant, anti-inflammation, anticancer, and antidiabetes. Our previous studies indicated that Myr protected mouse heart from lipopolysaccharide and streptozocin-induced injuries. However, it remained to be unclear whether Myr could prevent mouse heart from pressure overload-induced pathological hypertrophy. Wild type (WT) and cardiac Nrf2 knockdown (Nrf2-KD) mice were subjected to aortic banding (AB) surgery and then administered with Myr (200\u2009mg\/kg\/d) for 6 weeks. Myr significantly alleviated AB-induced cardiac hypertrophy, fibrosis, and cardiac dysfunction in both WT and Nrf2-KD mice. Myr also inhibited phenylephrine- (PE-) induced neonatal rat cardiomyocyte (NRCM) hypertrophy and hypertrophic markers\u2019 expression\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Mechanically, Myr markedly increased Nrf2 activity, decreased NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B activity, and inhibited TAK1\/p38\/JNK1\/2 MAPK signaling in WT mouse hearts. We further demonstrated that Myr could inhibit TAK1\/p38\/JNK1\/2 signaling via inhibiting Traf6 ubiquitination and its interaction with TAK1 after Nrf2 knockdown in NRCM. These results strongly suggested that Myr could attenuate pressure overload-induced pathological hypertrophy\n                    <jats:italic>in vivo<\/jats:italic>\n                    and PE-induced NRCM hypertrophy via enhancing Nrf2 activity and inhibiting TAK1\/P38\/JNK1\/2 phosphorylation by regulating Traf6 ubiquitination. Thus, Myr might be a potential strategy for therapy or adjuvant therapy for malignant cardiac hypertrophy.\n                  <\/jats:p>","DOI":"10.1155\/2019\/6304058","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T18:35:07Z","timestamp":1575657307000},"page":"1-14","source":"Crossref","is-referenced-by-count":53,"title":["Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6\/TAK1\/MAPK and Nrf2 Signaling Pathway"],"prefix":"10.1155","volume":"2019","author":[{"given":"Hai-han","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, Hubei 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, Hubei 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-yan","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, Hubei 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, Hubei 430060, 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