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Herein, the adjunctive use of statins in periodontal therapy <jats:italic>in vitro<\/jats:italic>, <jats:italic>in vivo<\/jats:italic>, and in clinical trials was reviewed. Statins act through several pathways to modulate inflammation, immune response, bone metabolism, and bacterial clearance. They control periodontal inflammation through inhibition of proinflammatory cytokines and promotion of anti-inflammatory and\/or proresolution molecule release, mainly, through the ERK, MAPK, PI3-Akt, and NF-<jats:italic>\u03ba<\/jats:italic>B pathways. Moreover, they are able to modulate the host response activated by bacterial challenge, to prevent inflammation-mediated bone resorption and to promote bone formation. Furthermore, they reduce bacterial growth, disrupt bacterial membrane stability, and increase bacterial clearance, thus averting the exacerbation of infection. Local statin delivery as adjunct to both nonsurgical and surgical periodontal therapies results in better periodontal treatment outcomes compared to systemic delivery. Moreover, combination of statin therapy with other regenerative agents improves periodontal healing response. Therefore, statins could be proposed as a potential adjuvant to periodontal therapy. However, optimization of the combination of their dose, type, and carrier could be instrumental in achieving the best treatment response.<\/jats:p>","DOI":"10.1155\/2019\/6367402","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T19:35:00Z","timestamp":1551296100000},"page":"1-33","source":"Crossref","is-referenced-by-count":77,"title":["Contribution of Statins towards Periodontal Treatment: A Review"],"prefix":"10.1155","volume":"2019","author":[{"given":"Catherine","family":"Petit","sequence":"first","affiliation":[{"name":"INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de Chirurgie-dentaire, 8 rue Sainte-Elisabeth, 67000 Strasbourg, France"},{"name":"H\u00f4pitaux Universitaires de Strasbourg, P\u00f4le de M\u00e9decine et Chirurgie 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