{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:17:32Z","timestamp":1778919452129,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias","award":["PI13\/01261"],"award-info":[{"award-number":["PI13\/01261"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["PI16\/02069"],"award-info":[{"award-number":["PI16\/02069"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["PI13\/01261"],"award-info":[{"award-number":["PI13\/01261"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["PI16\/02069"],"award-info":[{"award-number":["PI16\/02069"]}]},{"name":"Fondos Feder","award":["PI13\/01261"],"award-info":[{"award-number":["PI13\/01261"]}]},{"name":"Fondos Feder","award":["PI16\/02069"],"award-info":[{"award-number":["PI16\/02069"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:p>Dronedarone is recommended for the treatment of atrial fibrillation. However, we do not know its effect on vascular remodeling. This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling induced by chronic hypertension. Ten-month-old male spontaneously hypertensive rats (SHR) were randomly assigned to receive dronedarone (100\u2009mg\/kg) or vehicle. Age-matched male Wistar-Kyoto rats served as controls. After 14 days of treatment, we studied the structure (geometry and fibrosis) of the intramyocardial artery using histological analysis. Nitric oxide (NO) in plasma was analyzed. In the untreated SHR, we observed a significant increase in external diameter, lumen diameter, wall width, cross-sectional area, and collagen volume density, as was expected in the experimental model. Dronedarone induced a significant decrease in wall width, cross-sectional area, and collagen volume density in SHR-D in comparison with untreated SHR. The values obtained in SHR-D were similar in the WKY control group. We found significantly higher NO levels in plasma in SHR-D than in untreated SHR. Dronedarone improves the intramyocardial artery remodeling induced by chronic hypertension in SHR through increased nitric oxide bioavailability.<\/jats:p>","DOI":"10.1155\/2019\/6374582","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T19:35:35Z","timestamp":1562096135000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-2841","authenticated-orcid":true,"given":"Bego\u00f1a","family":"Quintana-Villamandos","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Reanimation and Intensive Care, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Department of Pharmacology and Toxicology, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Delgado-Martos","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Universidad Francisco de Vitoria, 28223 Madrid, Spain"},{"name":"Molecular Biology Laboratory, Department of Experimental Medicine and Surgery, Health Research Institute of Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Delgado-Baeza","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Department of Experimental Medicine and Surgery, Health Research Institute of Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.08.028"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/hy09t1.096249"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-010-0117-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/140174398428009"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363991-00003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2016.02.008"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-011-0086-1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0803778"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12128"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188442"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001345"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2016.11.002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.01.009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1988.tb05320.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/531087"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(07)00823-3"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2000.0319"},{"issue":"3","key":"18","first-page":"327","volume":"58","year":"2009","journal-title":"Physiological Research"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816040-00007"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328340a08e"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.69.1.107"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.57"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/HPC.0b013e3181dda1e6"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S8445"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/808353"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/801896"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn022"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.05.046"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x03vm501ed"},{"issue":"1","key":"30","first-page":"37","volume":"49","year":"2000","journal-title":"Physiological Research"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2014.974551"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01784.x"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/6374582.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/6374582.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/6374582.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T19:35:42Z","timestamp":1562096142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/6374582\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":32,"alternative-id":["6374582","6374582"],"URL":"https:\/\/doi.org\/10.1155\/2019\/6374582","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]}}}