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Pain is a complex experience integrating sensory, affective, and cognitive processes related to several peripheral and central nociceptive factors besides inflammation. During the last years, the role of infrapatellar fat pad (IFP), other than the synovial membrane, has been investigated as a potential source of pain in OA. Interestingly, new findings suggest that IFP and synovial membrane might act as a functional unit in OA pathogenesis and pain. The present review discuss the role of IFP and synovial membrane in the development of OA, with a particular focus on pain onset and the possible involved mediators that may play a role in OA pathology and pain mechanisms. Inflammation of IFP and synovial membrane may drive peripheral and central sensitization in KOA. Since sensitization is associated with pain severity in knee OA and may potentially contribute to the transition from acute to chronic, persistent pain in knee OA, preventing sensitization would be a potentially effective and novel means of preventing worsening of pain in knee OA.<\/jats:p>","DOI":"10.1155\/2019\/6390182","type":"journal-article","created":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T19:31:09Z","timestamp":1554060669000},"page":"1-18","source":"Crossref","is-referenced-by-count":183,"title":["Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1129-2574","authenticated-orcid":true,"given":"Elisa","family":"Belluzzi","sequence":"first","affiliation":[{"name":"Musculoskeletal Pathology and Oncology Laboratory, Department of Orthopaedics and Orthopaedic Oncology, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-622X","authenticated-orcid":true,"given":"Elena","family":"Stocco","sequence":"additional","affiliation":[{"name":"Institute of Human Anatomy, Department of Neuroscience, University of Padova, Italy"},{"name":"L.i.f.e.L.a.b. 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