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However, our understanding of the pathogenic mechanisms involved is poor and there have been few pathological studies of\n                    <jats:italic>Elizabethkingia<\/jats:italic>\n                    spp. in animals. To understand the host injury induced by\n                    <jats:italic>Elizabethkingia<\/jats:italic>\n                    spp., we established a model of\n                    <jats:italic>E. miricola<\/jats:italic>\n                    infection in the black-spotted frog (\n                    <jats:italic>Pelophylax nigromaculatus<\/jats:italic>\n                    ). The systematic pathology in and oxidative damage in the infection model were investigated. Our results show that recently isolated\n                    <jats:italic>E. miricola<\/jats:italic>\n                    is a bacterium that mainly parasitizes the host brain and that neurogenic organs are the predominant sites of damage. Infection mainly manifested as severe brain abscesses, meningoencephalitis, necrotic spondylitis, and necrotic retinitis. The liver, spleen, kidney, gastrointestinal tract, and lung were also affected to varying degrees, with bacterial necrotic inflammation.\n                    <jats:italic>P. nigromaculatus<\/jats:italic>\n                    also suffered enormous damage to its oxidative system during\n                    <jats:italic>E. miricola<\/jats:italic>\n                    infection, which may have further aggravated its disease state. Our results provide a preliminary reference for the study and treatment of\n                    <jats:italic>Elizabethkingia<\/jats:italic>\n                    spp.\n                    <jats:italic>-<\/jats:italic>\n                    induced neurological diseases in animals.\n                  <\/jats:p>","DOI":"10.1155\/2019\/6407524","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T19:30:36Z","timestamp":1568835036000},"page":"1-13","source":"Crossref","is-referenced-by-count":20,"title":["Candidate Animal Disease Model of\n                    <i>Elizabethkingia<\/i>\n                    Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by\n                    <i>E. miricola<\/i>\n                    in\n                    <i>Pelophylax nigromaculatus<\/i>"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-4779","authenticated-orcid":true,"given":"Xiaoli","family":"Huang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-4817","authenticated-orcid":true,"given":"Yang","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Tang","sequence":"additional","affiliation":[{"name":"Chengdu Academy of Agricultural and Forestry Sciences, Chengdu, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqing","family":"Xiong","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Chengdu Academy of Agricultural and Forestry Sciences, Chengdu, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucen","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, 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