{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:21:26Z","timestamp":1784769686424,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Support Program of China","award":["2013BAD16B08"],"award-info":[{"award-number":["2013BAD16B08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,6,11]]},"abstract":"<jats:p>Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species<jats:italic> Auricularia auricular<\/jats:italic> (AAPS-iron(III)). The highest iron content (28.40%) in the AAPS-iron(III) complex was obtained under the optimized preparation conditions including an AAPS to FeCl<jats:sub>3<jats:italic>\u2219<\/jats:italic><\/jats:sub>6H<jats:sub>2<\/jats:sub>O ratio of 2:3 (w\/w), a pH value of 8.0 in solution, a reaction temperature of 50\u00b0C, and a reaction time of 3 h. The physical and chemical properties of the AAPS-iron(III) complex were characterized by qualitative and quantitative analyses using scanning electron microscope, particle size distribution, thermogravimetric analyzer, Fourier transform infrared spectroscopy, circular dichroism, and <jats:sup>1<\/jats:sup>H nuclear magnetic resonance. Result showed that, although the iron was bound to the polysaccharide, it was released under artificial gastrointestinal conditions. The AAPS-iron(III) complex exhibited high stability (under 50-256\u00b0C) and water solubility. The AAPS-iron(III) complex also showed high antioxidant activity in vitro, demonstrating an additional health benefit over other typical nonantioxidant iron nutritional supplements. Furthermore, the AAPS-iron(III) complex showed high efficiency on the treatment of the iron deficiency anemia in the model rats. Therefore, the AAPS-iron(III) complex can be used as a nutritional fortifier to supply iron in industrial processing and to assist the treatment of iron deficiency anemia.<\/jats:p>","DOI":"10.1155\/2019\/6416941","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T19:31:23Z","timestamp":1560281483000},"page":"1-14","source":"Crossref","is-referenced-by-count":20,"title":["Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in<i> Auricularia auricula<\/i> Potentially Used as an Iron Supplement"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-862X","authenticated-orcid":true,"given":"Tong","family":"Liu","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, Jilin Agricultural University, Changchun, 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