{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:29:15Z","timestamp":1762507755079,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460515","AB17292074"],"award-info":[{"award-number":["81460515","AB17292074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Science and Technology Research and Development Program Project of Guangxi","award":["81460515","AB17292074"],"award-info":[{"award-number":["81460515","AB17292074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,5,9]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). Abundant evidence indicates that abnormal expression of Pc proteins is associated with a variety of tumors, but their role in the pathogenesis of hepatocellular carcinoma (HCC) has not been fully elucidated. In the present study, we performed a case-control study to investigate the relationship between single nucleotide polymorphisms (SNPs) of<jats:italic>CBX<\/jats:italic>genes and HCC.<jats:italic>Methods<\/jats:italic>. Nine SNPs on<jats:italic>CBX<\/jats:italic>genes (rs7217395, rs2036316 of<jats:italic>CBX2<\/jats:italic>; rs3764374, rs1285251, rs2289728 of<jats:italic>CBX4<\/jats:italic>; rs7292074 of<jats:italic>CBX6<\/jats:italic>; and rs710190, rs139394, rs5750753 of<jats:italic>CBX7<\/jats:italic>) were screened and genotyped using MassARRAY technology in 334 HCC cases and 321 controls. The association between SNPs and their corresponding gene expressions was analyzed through bioinformatics methods using the Ensembl database and Blood eQTL browser online tools.<jats:italic>Results<\/jats:italic>. The results indicated that rs2289728 (G&gt;A) of<jats:italic>CBX4<\/jats:italic>(<jats:italic>P<\/jats:italic>= 0.03, OR = 0.56, 95% CI: 0.33-0.94) and rs139394 (C&gt;A) of<jats:italic>CBX7<\/jats:italic>(<jats:italic>P<\/jats:italic>= 0.02, OR = 0.55, 95% CI: 0.33-0.90) decreased the risk of HCC. Interaction between rs2036316 and HBsAg increased the risk of HCC (<jats:italic>P<\/jats:italic>= 0.02, OR = 6.88, 95% CI: 5.20-9.11), whereas SNP-SNP interaction between rs710190 and rs139394 reduced the risk of HCC (<jats:italic>P<\/jats:italic>= 0.03, OR = 0.33, 95% CI: 0.12-0.91). Gene expression analyses showed that the rs2289728 A allele and the rs139394 A allele significantly reduced<jats:italic>CBX4<\/jats:italic>and<jats:italic>CBX7<\/jats:italic>expression, respectively.<jats:italic>Conclusion<\/jats:italic>. Our findings suggest that<jats:italic>CBX4<\/jats:italic>rs2289728 and<jats:italic>CBX7<\/jats:italic>rs139394 are protective SNPs against HCC. The two SNPs may reduce the risk of HCC while suppressing the expression of<jats:italic>CBX4<\/jats:italic>and<jats:italic>CBX7<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2019\/6436825","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T23:31:18Z","timestamp":1557444678000},"page":"1-8","source":"Crossref","is-referenced-by-count":14,"title":["Single Nucleotide Polymorphisms of<i>CBX4<\/i>and<i>CBX7<\/i>Decrease the Risk of Hepatocellular Carcinoma"],"prefix":"10.1155","volume":"2019","author":[{"given":"Chao","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7515-3464","authenticated-orcid":true,"given":"Chunhua","family":"Bei","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyuan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-0868","authenticated-orcid":true,"given":"Shengkui","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, 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