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To investigate the longitudinal findings of fundus features and spectral-domain optical coherence tomography (SD-OCT) to characterize the morphologic features in a mouse model of defective glutamate\/aspartate transporter (GLAST<jats:sup>\u2212\/\u2212<\/jats:sup> mice). <jats:italic>Materials and Methods<\/jats:italic>. The fundus findings and SD-OCT images were longitudinally recorded at five time points from postnatal (P) 22 to P156 in GLAST<jats:sup>\u2212\/\u2212<\/jats:sup> mice. As a control wild type, age-matched C57BL\/6J mice were employed. The mouse retina was subdivided into five layers, and the thickness of each layer was longitudinally measured by InSight\u00ae using SD-OCT pictures. The SD-OCT findings were compared with the histologic appearances. The diameter of the retinal blood vessels was measured by the ImageJ\u00ae software program using SD-OCT images. The data were statistically compared between both age-matched mouse groups. <jats:italic>Results<\/jats:italic>. The retinal blood vessels appeared more dilated in GLAST<jats:sup>\u2212\/\u2212<\/jats:sup> mice than in wild-type mice. This tendency was statistically significant at all time points after P44 by analyses using SD-OCT images. The ganglion cell complex (GCC) and outer nuclear layer (ONL) were significantly thinner in GLAST<jats:sup>\u2212\/\u2212<\/jats:sup> mice at all time points after P80 than in the wild-type mice. This tendency was more clearly indicated by SD-OCT than histologic sections. <jats:italic>Discussion<\/jats:italic>. In the present study, we found for the first time the dilation of the retinal blood vessels and the thinning of the ONL in GLAST<jats:sup>\u2212\/\u2212<\/jats:sup> mice, in addition to the thinning of the GCC.<\/jats:p>","DOI":"10.1155\/2019\/6512195","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T18:34:07Z","timestamp":1573497247000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["Excess Glutamate May Cause Dilation of Retinal Blood Vessels in Glutamate\/Aspartate Transporter-Deficient Mice"],"prefix":"10.1155","volume":"2019","author":[{"given":"Takayuki","family":"Gonome","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 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