{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:26Z","timestamp":1740171806927,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hunan Provincial Key Laboratory of Pediatric Emergency Medicine","award":["2018TP1028","2018JJ2210","201710010086"],"award-info":[{"award-number":["2018TP1028","2018JJ2210","201710010086"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2018TP1028","2018JJ2210","201710010086"],"award-info":[{"award-number":["2018TP1028","2018JJ2210","201710010086"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009334","name":"Pearl River S and T Nova Program of Guangzhou","doi-asserted-by":"publisher","award":["2018TP1028","2018JJ2210","201710010086"],"award-info":[{"award-number":["2018TP1028","2018JJ2210","201710010086"]}],"id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2019,9,10]]},"abstract":"<jats:p>Neuroblastoma is the most common seen solid neural tumor in children less than age one. As mutation in the<jats:italic>miR-34b\/c<\/jats:italic>gene is observed in several types of human malignancies, there likely to be similar events that contribute to the pathogenesis of neuroblastoma. We hypothesize that polymorphism in the<jats:italic>miR-34b\/c<\/jats:italic>gene might predispose to neuroblastoma. Here, we conducted this replication study by genotyping rs4938723 T&gt;C from<jats:italic>miR-34b\/c<\/jats:italic>in Hunan children (162 subjects with neuroblastoma and 270 control subjects) and examined its effect on the risk of neuroblastoma. We determined such association using logistic regression, adjusted for age and gender. Relative to those with TT genotype, subjects with C allele had reduced neuroblastoma risk (TC vs. TT: adjusted<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.46<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.30<\/mml:mn><mml:mo>\u2010<\/mml:mo><mml:mn>0.71<\/mml:mn><\/mml:math>; additive model: adjusted<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.64<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.47<\/mml:mn><mml:mo>\u2010<\/mml:mo><mml:mn>0.88<\/mml:mn><\/mml:math>; TC\/CC vs. TT: adjusted<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.49<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn>95<\/mml:mn><mml:mi>%<\/mml:mi><mml:mtext>CI<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.33<\/mml:mn><mml:mo>\u2010<\/mml:mo><mml:mn>0.73<\/mml:mn><\/mml:math>). Stratified analysis revealed that rs4938723 TC\/CC carriers were less likely to develop neuroblastoma for patients in the subgroups of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mtext>age<\/mml:mtext><mml:mo>\u2264<\/mml:mo><mml:mn>18<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>months<\/mml:mtext><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mtext>age<\/mml:mtext><mml:mo>&gt;<\/mml:mo><mml:mn>18<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mtext>months<\/mml:mtext><\/mml:math>, females, males, tumors in retroperitoneal, tumors in other sites, and clinical stages II, III, IV, and III+IV. Our findings verified<jats:italic>miR-34b\/c<\/jats:italic>rs4938723 C variant allele as a protective factor for the risk of neuroblastoma. Further investigation of how<jats:italic>miR-34b\/c<\/jats:italic>rs4938723 T&gt;C might modify neuroblastoma risk is warranted.<\/jats:p>","DOI":"10.1155\/2019\/6514608","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T23:30:58Z","timestamp":1568158258000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["<i>miR-34b\/c<\/i>rs4938723 T&gt;C Decreases Neuroblastoma Risk: A Replication Study in the Hunan Children"],"prefix":"10.1155","volume":"2019","author":[{"given":"Yong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha, 410004 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Jian","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, 510623 Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiang-ya School of Medicine, Central South University, Changsha, 410013 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-2415","authenticated-orcid":true,"given":"Jiabin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, 510623 Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Emergency Center of Hunan Children\u2019s Hospital, Changsha, 410004 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha, 410004 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-2892","authenticated-orcid":true,"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, 510623 Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-017X","authenticated-orcid":true,"given":"Zan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hunan Children\u2019s Hospital, Changsha, 410004 Hunan, 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