{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:56:22Z","timestamp":1787853382936,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2019,4,18]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. We aimed to compare the results of neointimal modification before drug-coated balloon (DCB) treatment with excimer laser coronary atherectomy (ELCA) plus scoring balloon predilation versus scoring balloon alone in patients presenting with in-stent restenosis (ISR).<jats:italic>Background<\/jats:italic>. Treatment of ISR with ELCA typically results in superior acute gain by neointima debulking. However, the efficacy of combination therapy of ELCA and DCB remains unknown.<jats:italic>Methods<\/jats:italic>. A total of 42 patients (44 ISR lesions) undergoing DCB treatment with ELCA plus scoring balloon (ELCA group, n = 18) or scoring balloon alone (non-ELCA group, n = 24) were evaluated via serial assessment by optical coherence tomography (OCT) performed before, after intervention, and at 6 months.<jats:italic>Results<\/jats:italic>. Although there was significantly greater frequency of diffuse restenosis and percent diameter stenosis (%DS) after intervention in the ELCA group, comparable result was shown in %DS, late lumen loss, and binary angiographic restenosis at follow-up. On OCT analysis, a decreased tendency in the minimum lumen area and a significant decrease in the minimum stent area were observed in the ELCA group between 6-month follow-up and after intervention (-0.89 \u00b1 1.36 mm<jats:sup>2<\/jats:sup>vs. -0.09 \u00b1 1.25 mm<jats:sup>2<\/jats:sup>, p = 0.05, -0.49 \u00b1 1.48 mm<jats:sup>2<\/jats:sup>vs. 0.28 \u00b1 0.78 mm<jats:sup>2<\/jats:sup>, p = 0.03, respectively). The changes in the neointimal area were similar between the groups, and target lesion revascularization showed comparable rates at 1 year (11.1% vs. 11.4%, p = 0.85).<jats:italic>Conclusions<\/jats:italic>. Despite greater %DS after intervention, ELCA before DCB had possible benefit for late angiographic and clinical outcome.<\/jats:p>","DOI":"10.1155\/2019\/6515129","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T23:45:39Z","timestamp":1555631139000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-7781","authenticated-orcid":true,"given":"Toru","family":"Miyazaki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Disaster Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Otomo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, 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