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Parkinson\u2019s disease is generally characterized by a severe loss of dopaminergic neurons in the nigrostriatal pathway, with substantial neuroinflammation and motor deficits. This was experimentally replicated in animal models, using neurotoxins, i.e., LPS (lipopolysaccharides) and MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).<jats:italic>Salicornia europaea<\/jats:italic>L. (SE) has been used as a dietary supplement in Korea and Europe for several years, due to its nutritional and therapeutic value. In this study, we intend to investigate the antineuroinflammatory and anti-PD-like effects of the bioactive fraction\/candidate of the SE extract. Initially, we screened various fractions of SE extract using an<jats:italic>in vitro<\/jats:italic>antioxidant assay. The optimal fraction was investigated for its<jats:italic>in vitro<\/jats:italic>antineuroinflammatory potential in LPS-stimulated BV-2 microglial cells and<jats:italic>in vivo<\/jats:italic>anti-PD-like potential in MPTP-intoxicated mice. Subsequently, to identify the potential candidate responsible for the elite therapeutic potential of the optimal fraction, we conducted antioxidant activity-guided isolation and purification; the bioactive candidate was structurally characterized using nuclear magnetic resonance spectroscopy and chromatographic techniques and further investigated for its<jats:italic>in vitro<\/jats:italic>antioxidative and antineuroinflammatory potential. The results of our study indicate that SE-EA and its bioactive candidate, Irilin B, effectively alleviate the deleterious effect of microglia-mediated neuroinflammation and promote antioxidative effects. Thus, they exhibit potential as therapeutic candidates against neuroinflammatory and oxidative stress-mediated PD-like neurodegenerative complications.<\/jats:p>","DOI":"10.1155\/2019\/6764756","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T23:31:07Z","timestamp":1562715067000},"page":"1-16","source":"Crossref","is-referenced-by-count":14,"title":["The Ameliorative Effects of the Ethyl Acetate Extract of<i>Salicornia europaea<\/i>L. and Its Bioactive Candidate, Irilin B, on LPS-Induced Microglial Inflammation and MPTP-Intoxicated PD-Like Mouse Model"],"prefix":"10.1155","volume":"2019","author":[{"given":"Joonsoo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Applied Life Sciences, Graduate school of Konkuk University, Research Institute of Inflammatory Diseases, Chungju 27478, Republic of 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