{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:38:09Z","timestamp":1774607889305,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FIPE\/HCPA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2019,5,13]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic> Spontaneous bacterial peritonitis (SBP) has a deleterious clinical impact in end-stage liver disease, and multidrug resistance has increased, raising concern about effectiveness of traditional antibiotic regimens.<jats:italic> Patients and Methods<\/jats:italic>. Single-center retrospective study of ascitic fluid infections in cirrhotic patients.<jats:italic> Results<\/jats:italic>. We analyzed medical records related to 2129 culture-positive ascitic fluid and found 183 samples from cirrhotic patients. There were 113 monobacterial SBP cases from 97 cirrhotic patients; 57% of patients were male; hepatitis C and alcohol were the main etiologies for cirrhosis. Multidrug resistant bacteria were isolated in 46.9% of SBP samples, and third-generation cephalosporin and quinolone resistant reached 38.9% and 25.7% of SBP cases.<jats:italic> Conclusion<\/jats:italic>. SBP due to multidrug resistant bacteria is a growing problem, and one should consider reported resistance profiles for the decision-making process of empirical first-line treatment prescription.<\/jats:p>","DOI":"10.1155\/2019\/6963910","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T19:31:02Z","timestamp":1557775862000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["High Prevalence of Multidrug Resistant Bacteria in Cirrhotic Patients with Spontaneous Bacterial Peritonitis: Is It Time to Change the Standard Antimicrobial Approach?"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-3068","authenticated-orcid":true,"given":"Jer\u00f4nimo De Conto","family":"Oliveira","sequence":"first","affiliation":[{"name":"Post-Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, 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