{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:21:41Z","timestamp":1773922901138,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2019,3,3]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Despite the high prevalence of the HIV\/AIDS, few studies focused on the prevalence of lipodystrophy in pediatric HIV patients on antiretroviral therapy (ARV) in sub-Saharan African countries. The aim of this study was to assess the prevalence and to identify the risk factors of metabolic disorders related to ARV therapy in this population.<jats:italic>Methods<\/jats:italic>. A cross-sectional study was completed in Kinshasa, the Democratic Republic of Congo. HIV-infected children aged between six and 18 years on ARV were consecutively recruited. For each case, two control children (one non-HIV infected child and one HIV-infected antiretroviral therapy-na\u00efve child) were also recruited.<jats:italic>Results<\/jats:italic>. 80 HIV-infected on ARV therapy children (group 1), 80 noninfected children (group 2) and 65 HIV-infected antiretroviral therapy-na\u00efve children (group 3) were recruited. The frequency of lipoatrophy was not statistically different between group 1 (16.3%) and group 3 (21.5%). A significantly higher proportion of lipohypertrophy, hypercholesterolemia, and lactic acidosis was noted in children of group 1, compared to the controls (p&lt;0.05). Mixed form was rarely observed in this series. The frequency of hypertriglyceridemia was not different between the 3 groups (p&gt;0.05).<jats:italic>Conclusion<\/jats:italic>. Lipohypertrophy, hypercholesterolemia, and lactic acidosis emerge as a frequent metabolic disorders due to ARV therapy.<\/jats:p>","DOI":"10.1155\/2019\/7013758","type":"journal-article","created":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T23:34:46Z","timestamp":1551656086000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: A First Report from the Central Africa"],"prefix":"10.1155","volume":"2019","author":[{"given":"Honor\u00e9 Kalombayi","family":"Tshamala","sequence":"first","affiliation":[{"name":"Division of Cardiology and Infectious Diseases, Department of Pediatrics, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loukia","family":"Aketi","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Infectious Diseases, Department of Pediatrics, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Manianga","family":"Tshibassu","sequence":"additional","affiliation":[{"name":"Division of Neurology, Nutrition and Gastroenterology, Department of Paediatrics, University Hospital of Kinshasa, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde Bothale","family":"Ekila","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric Musalu","family":"Mafuta","sequence":"additional","affiliation":[{"name":"Division of 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