{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:35:40Z","timestamp":1747190140325,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2019,11,5]]},"abstract":"<jats:p>A 55-year-old female with a past medical history of cocaine use and hypertension was admitted for intracranial hemorrhage requiring right decompressive craniotomy with duraplasty. Due to persistent fevers, a head CT scan obtained on day 28 of hospitalization identified a low-density subgaleal fluid collection overlying the duraplasty. Aspiration of this collection was sent for culture which grew 2+ <jats:italic>Enterobacter cloacae<\/jats:italic> complex susceptible to sulfamethoxazole-trimethoprim (SMX-TMP), gentamicin, ciprofloxacin, and ertapenem. Based on these results, the patient was transitioned from empiric vancomycin and ceftazidime to SMX-TMP and metronidazole. Despite treatment with SMX-TMP and metronidazole, aspirated subgaleal collection cultures remained positive for <jats:italic>E. cloacae<\/jats:italic>. Intrathecal gentamicin was therefore added; however, repeat subgaleal culture collections remained persistently positive. Given the persistently positive subgaleal culture collections, the patient was transitioned from SMX-TMP and metronidazole to ertapenem. After transition to ertapenem, subgaleal cultures were sterilized and the patient\u2019s infection was resolved. This report suggests ertapenem may be a viable option for central nervous system infections; however, further study is needed.<\/jats:p>","DOI":"10.1155\/2019\/7021586","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T18:32:17Z","timestamp":1572978737000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Successful Use of Ertapenem for the Treatment of <i>Enterobacter cloacae<\/i> Complex Infection of the Central Nervous System (CNS)"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-1451","authenticated-orcid":true,"given":"Sunish","family":"Shah","sequence":"first","affiliation":[{"name":"Yale New Haven Hospital, Department of Pharmacy Services, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayna","family":"McManus","sequence":"additional","affiliation":[{"name":"Yale New Haven Hospital, Department of Pharmacy Services, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey E.","family":"Topal","sequence":"additional","affiliation":[{"name":"Yale New Haven Hospital, Department of Pharmacy Services, New Haven, CT, USA"},{"name":"Yale School of Medicine, Department of Internal Medicine, Section of Infectious Diseases, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"169","volume":"127","year":"1977","journal-title":"Western Journal of medicine"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/1992\/652358"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw861"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.3.1.23"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt091"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1128\/aac.47.6.1943-1947.2003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-8-585"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/bf01963940"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90071-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1086\/317462"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-6-881"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00007-10"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir197"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2009.01550.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/aac.45.11.2977-2986.2001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.11.040"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767070-00006"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh203"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1177\/2324709616689376"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-017-0578-2"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2019\/7021586.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2019\/7021586.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2019\/7021586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T18:32:20Z","timestamp":1572978740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criid\/2019\/7021586\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,5]]},"references-count":20,"alternative-id":["7021586","7021586"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7021586","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"type":"print","value":"2090-6625"},{"type":"electronic","value":"2090-6633"}],"subject":[],"published":{"date-parts":[[2019,11,5]]}}}