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Uncontrolled blood pressure is the leading cause of mortality and disability due to associated cerebral and cardiovascular diseases and kidney failure. More than one-third of the old adult population have hypertension or prehypertension and many of their blood pressure are poorly controlled.<jats:italic>Objective<\/jats:italic>. We hypothesized that plant extracts-based antioxidants may benefit those with prehypertension\/hypertension.<jats:italic>Method<\/jats:italic>. One hundred age- and gender-matched healthy older adults were randomly assigned to receive HyperBalance capsules (n=50) or placebo (n=50) at Tang-Qiao Community Health Service Center, Shanghai. Blood pressure and severity scores of hypertension treatment-related symptoms (dizziness, headache, ringing\/buzzing in ears, rapid heart rate, and chest tightness) were evaluated before and after the 12-week intervention.<jats:italic>Results<\/jats:italic>. Ninety-eight people completed the study, with 2 dropouts in the placebo group before the end of the study. Forty-one subjects (82%) of the HyperBalance group and 40 subjects (83.3%) of the placebo group had prehypertension (systolic blood pressures (SBP) between 130-139 and diastolic blood pressure (DBP) between 85-89mmHg), and 9 subjects (18%) in the HyperBalance group and 8 subjects (16.7%) in the placebo group had hypertension (\u2265140\/90mmHg) before the intervention. HyperBalance significantly (P&lt;0.01) reduced SBP from 136.18\u00b14.38 to 124.14\u00b13.96 mmHg and reduced DBP from 82.45\u00b12.91 to 80.24\u00b12.41mmHg, respectively, and reversed all 9 hypertension people to normotension or prehypertension state, whereas the placebo moderately reduced SBP from 135.79\u00b14.22 to 132.35\u00b14.656mmHg and reduced DBP from 82.90\u00b13.07 to 82.27\u00b13.01mmHg. All symptom severity scores became significantly lower in the HyperBalance group than in the placebo group after HyperBalance intervention: dizziness (0.82\u00b10.44; vs 2.02\u00b10.64, P&lt;0.01); headache (0.46\u00b10.50; vs 1.81\u00b10.61, P&lt;0.01); ringing\/buzzing in ears (0.44\u00b10.50; vs 1.04\u00b10.29, P&lt;0.01); and rapid heart rate and chest tightness (0.30\u00b10.46; vs 0.92\u00b10.28, P&lt;0.01).<jats:italic>Conclusion<\/jats:italic>. Polyherbal supplementation such as HyperBalance could benefit old adults with prehypertension\/hypertension and improve treatment-related symptoms. Further studies are needed to validate the current findings.<\/jats:p>","DOI":"10.1155\/2019\/7056872","type":"journal-article","created":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T23:31:53Z","timestamp":1563147113000},"page":"1-15","source":"Crossref","is-referenced-by-count":5,"title":["Effects of 12-Week Supplementation of a Polyherbal Formulation in Old Adults with Prehypertension\/Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-6911","authenticated-orcid":true,"given":"Tian","family":"Shen","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4706-3063","authenticated-orcid":true,"given":"Guoqiang","family":"Xing","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital and the Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong 637000, China"},{"name":"Lotus Biotech.com LLC, John Hopkins University-MCC, 9601 Medical Center Drive, Rockville, MD 20850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0644-1205","authenticated-orcid":true,"given":"Jingfen","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-7906","authenticated-orcid":true,"given":"Yong","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghua","family":"Li","sequence":"additional","affiliation":[{"name":"Tang Qiao Community Health Service Center, Pudong New District, Shanghai 200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyu","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-3026","authenticated-orcid":true,"given":"Rong","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"journal-title":"NCHS Data Brief, No. 133. 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