{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:14:06Z","timestamp":1773695646344,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,16]],"date-time":"2019-06-16T00:00:00Z","timestamp":1560643200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2019,6,16]]},"abstract":"<jats:p>Antitumor necrosis factor-<jats:italic>\u03b1<\/jats:italic> therapy has been used effectively in treatment of many inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease. There are increasing number of paradoxical reactions associated with this therapy that are being reported. We present the case of a 63-year-old male with psoriatic arthritis maintained on adalimumab and methotrexate (previous treatment trials of prednisone and leflunomide) who developed severe symptomatic sarcoidosis in the brain, liver, and lung. Upon discontinuation of adalimumab, the symptoms resolved but the imaging findings persisted. Although the development of sarcoidosis (usually in the lung, skin, and eyes) while on antitumor necrosis factor-<jats:italic>\u03b1<\/jats:italic> therapy is increasingly reported, the brain and liver are less commonly involved but should be borne in mind by physicians when extensive granulomatous lesions develop.<\/jats:p>","DOI":"10.1155\/2019\/7121539","type":"journal-article","created":{"date-parts":[[2019,6,16]],"date-time":"2019-06-16T19:31:42Z","timestamp":1560713502000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Severe Symptomatic Central Nervous System Sarcoidosis Secondary to Treatment with Adalimumab"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1778-5345","authenticated-orcid":true,"given":"Benedicta Nneoma","family":"Nnodum","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Berkshire Medical Center, Pittsfield, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida P.","family":"Hariri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despoina","family":"Mavrommati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Berkshire Medical Center, Pittsfield, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Dudley","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Berkshire Medical Center, Pittsfield, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666x.2014.866038"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.06.005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1159\/000260371"},{"issue":"5","key":"4","first-page":"1040","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.31254\/jmr.2017.32012"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13159"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181efa190"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)12888-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12673"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-402oc"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1128\/cvi.00337-10"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.11.003"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.125"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw155"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-208188"},{"issue":"11","key":"16","first-page":"2313","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-212"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6726-9"}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2019\/7121539.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2019\/7121539.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2019\/7121539.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,16]],"date-time":"2019-06-16T19:31:44Z","timestamp":1560713504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crirh\/2019\/7121539\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,16]]},"references-count":18,"alternative-id":["7121539","7121539"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7121539","relation":{},"ISSN":["2090-6889","2090-6897"],"issn-type":[{"value":"2090-6889","type":"print"},{"value":"2090-6897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,16]]}}}