{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:19:01Z","timestamp":1789564741060,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","award":["RG-1439-293"],"award-info":[{"award-number":["RG-1439-293"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:p>In this experimental approach, we explored the structures, morphologies, phototoxicities, and antibacterial activities of undoped and Mn-doped ceria nanocomposite materials, Mn<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>Ce<jats:sub>1\u2212<jats:italic>x<\/jats:italic><\/jats:sub>O<jats:sub>2.<\/jats:sub> The Mn<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub>Ce<jats:sub>1\u2212<jats:italic>x<\/jats:italic><\/jats:sub>O<jats:sub>2<\/jats:sub> nanocomposites were synthesized by employing a soft chemical route. Our prime focus was on the influence of different factors, both physical and chemical, i.e., the concentration of manganese in the product, size of the nanocomposite, drug dose, and incubation time, on the bacterial strains. Different bacterial strains were selected as experimental biological models of the antibacterial activity of the manganese-doped cerium oxide nanocomposite. In addition to the photodynamic response, the adenocarcinoma cell line (MCF-7) was also studied. Based on cell viability losses and bacterial inhibition analyses, the precise mechanisms of apoptosis or necrosis of 5-ALA\/PpIX-exposed MCF-7 cells under 630\u2009nm red lights and under dark conditions were elucidated. It was observed that the undoped nanocomposites had lower cytotoxicities and inhibitions compared with those of the doped nanocomposites towards pathogens. The antibacterial activity and effectiveness for photodynamic therapy were enhanced in the presence of the manganese-doped ceria nanocomposite, which could be attributed to the correlation of the maximum reactive oxygen species generation for targeted toxicity and maximum antioxidant property in bacteria growth inhibition. The optimized cell viability dose and doping concentration will be beneficial for treating cancer and bacterial infections in the future.<\/jats:p>","DOI":"10.1155\/2019\/7156828","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T19:30:51Z","timestamp":1569439851000},"page":"1-13","source":"Crossref","is-referenced-by-count":59,"title":["Manganese-Doped Cerium Oxide Nanocomposite Induced Photodynamic Therapy in MCF-7 Cancer Cells and Antibacterial Activity"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-4275","authenticated-orcid":true,"given":"M.","family":"Atif","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-4726","authenticated-orcid":true,"given":"Seemab","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Physics, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5222-2700","authenticated-orcid":true,"given":"M.","family":"Fakhar-E-Alam","sequence":"additional","affiliation":[{"name":"Department of Physics, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Genetic Engineering, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qaisar","family":"Mansoor","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Genetic Engineering, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Mughal","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Genetic Engineering, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Hammad","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Physics, Comsats University Lahore Campus, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-7041","authenticated-orcid":true,"given":"Atif","family":"Hanif","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2479-475X","authenticated-orcid":true,"given":"W. 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