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Cardiology"],"published-print":{"date-parts":[[2019,3,11]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. In a separate, contemporary cohort, we sought to confirm findings of the original Women\u2019s Ischemia Syndrome Evaluation (WISE).<jats:italic> Background<\/jats:italic>. The original WISE observed a high prevalence of both invasively determined coronary endothelial and coronary microvascular dysfunction (CMD) that predicted adverse events in follow-up.<jats:italic> Methods<\/jats:italic>. We comparatively studied the WISE-Coronary Vascular Dysfunction (CVD) cohort (2009-2011), with signs and symptoms of ischemia but without significant CAD, to the original WISE (1997-2001) cohort. CMD was defined as coronary flow reserve (CFR) \u22642.5, or endothelial dysfunction as epicardial coronary artery constriction to acetylcholine (ACH), or &lt;20% epicardial coronary dilation to nitroglycerin (NTG).<jats:italic> Results<\/jats:italic>. In WISE (n=181) and WISE-CVD (n=235) women, mean age in both was 54 years, and 83% were white (WISE) vs 74% (WISE-CVD, p=0.04). Use of hormone replacement therapy was less frequent in WISE-CVD vs WISE (46% vs 57%, p=0.026) as was presence of hypertension (40% vs 52%, p=0.013), hyperlipidemia (20% vs 46%, p&lt;0.0001), and smoking (46% vs 56%, p=0.036). Similar rates were observed in WISE-CVD and WISE cohorts for CMD (mean CFR 2.7\u00b10.6 vs 2.6\u00b10.8, p=0.35), mean change in diameter with intracoronary ACH (0.2\u00b110.0 vs 1.6\u00b112.8 mm, p=0.34), and mean change in diameter with intracoronary NTG (9.7\u00b113.0 vs 9.8\u00b113.5 mm, p=0.94), respectively.<jats:italic> Conclusions<\/jats:italic>. This study confirms prevalence of CMD in the contemporary WISE-CVD cohort similar to that of the original WISE cohort, despite a lower risk factor burden in WISE-CVD. Because these coronary functional abnormalities predict major adverse cardiac events, clinical trials of therapies targeting these abnormalities are indicated.<\/jats:p>","DOI":"10.1155\/2019\/7169275","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T19:31:03Z","timestamp":1552332663000},"page":"1-8","source":"Crossref","is-referenced-by-count":30,"title":["Prevalence of Coronary Endothelial and Microvascular Dysfunction in Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease Is Confirmed by a New Cohort: The NHLBI-Sponsored Women\u2019s Ischemia Syndrome Evaluation\u2013Coronary Vascular Dysfunction (WISE-CVD)"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-3286","authenticated-orcid":true,"given":"R. 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