{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:10:49Z","timestamp":1790680249082,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education (MOE), Malaysia","award":["FRGS\/1\/2016\/WAB11\/UIAM\/03\/1"],"award-info":[{"award-number":["FRGS\/1\/2016\/WAB11\/UIAM\/03\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,8,14]]},"abstract":"<jats:p><jats:italic>Piper sarmentosum<\/jats:italic> is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb\u2019s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of <jats:italic>Piper sarmentosum<\/jats:italic> leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3\u2009mg\/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5\u2009mg\/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) and reduced endothelin-1 (ET-1) level (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>) in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production.<\/jats:p>","DOI":"10.1155\/2019\/7198592","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T19:32:29Z","timestamp":1565811149000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["<i>Piper sarmentosum<\/i> Leaves Aqueous Extract Attenuates Vascular Endothelial Dysfunction in Spontaneously Hypertensive Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-614X","authenticated-orcid":true,"given":"Fatimatuzzahra","family":"Hashim Fauzy","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-8092","authenticated-orcid":true,"given":"Maizura","family":"Mohd Zainudin","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidayatul Radziah","family":"Ismawi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taher F. 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