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This represents a major health concern, given the high homology between these two viruses, which can result in cross-reactivity. The aim of this study was to determine the cross-reacting antibody response of the IgM and IgG classes against the recombinant envelope protein of ZIKV (rE-ZIKV) in sera from patients with acute-phase infection of different clinical forms of dengue, i.e., dengue fever (DF) and dengue hemorrhagic fever (DHF) (before the arrival of ZIKV in Mexico 2010), as well as acute-phase sera of ZIKV patients, together with the implications in neutralization and antibody-dependent enhancement. Differences in IgM responses were observed in a number of DF and DHF patients whose sera cross-reacted with the rE-ZIK antigen, with 42% recognition between acute-phase DHF and ZIKV but 27% recognition between DF and ZIKV. Regarding IgG antibodies, 71.5% from the DF group showed cross-reactivity to rE-ZIKV in contrast with 50% and only 25% of DHF and ZIKV serum samples, respectively, which specifically recognized the homologous antigen. The DHF group showed more enhancement of ZIKV infection of FCR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    -expressing cells compared to the DF group. Furthermore, the DHF group also showed a higher cross-neutralizing ability than that of DF. This is the first report where DF and DHF serum samples were evaluated for cross-reactivity against Zika protein and ZIKV. Furthermore, DENV serum samples cross-protect against ZIKV through neutralizing antibodies but at the same time mediate antibody-dependent enhancement in the sequential ZIKV infection.\n                  <\/jats:p>","DOI":"10.1155\/2019\/7239347","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T19:31:04Z","timestamp":1567452664000},"page":"1-14","source":"Crossref","is-referenced-by-count":28,"title":["Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population"],"prefix":"10.1155","volume":"2019","author":[{"given":"Mayra R.","family":"Montecillo-Aguado","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina Molecular, CINVESTAV IPN, Av. IPN # 2508 Col. 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