{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:25Z","timestamp":1787017705535,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Project of Guangdong Province","award":["2018A030307047"],"award-info":[{"award-number":["2018A030307047"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["2017A030313847"],"award-info":[{"award-number":["2017A030313847"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["81402116"],"award-info":[{"award-number":["81402116"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["A2018053"],"award-info":[{"award-number":["A2018053"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["180709154010294"],"award-info":[{"award-number":["180709154010294"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["2018A030307047"],"award-info":[{"award-number":["2018A030307047"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["2017A030313847"],"award-info":[{"award-number":["2017A030313847"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["81402116"],"award-info":[{"award-number":["81402116"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["A2018053"],"award-info":[{"award-number":["A2018053"]}]},{"name":"Science and Technology Project of Guangdong Province","award":["180709154010294"],"award-info":[{"award-number":["180709154010294"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018A030307047"],"award-info":[{"award-number":["2018A030307047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017A030313847"],"award-info":[{"award-number":["2017A030313847"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402116"],"award-info":[{"award-number":["81402116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["A2018053"],"award-info":[{"award-number":["A2018053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["180709154010294"],"award-info":[{"award-number":["180709154010294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["2018A030307047"],"award-info":[{"award-number":["2018A030307047"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["2017A030313847"],"award-info":[{"award-number":["2017A030313847"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["81402116"],"award-info":[{"award-number":["81402116"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["A2018053"],"award-info":[{"award-number":["A2018053"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["180709154010294"],"award-info":[{"award-number":["180709154010294"]}]},{"name":"Shantou Science and Technology Project-Medical Treatment and Public Health Category","award":["2018A030307047"],"award-info":[{"award-number":["2018A030307047"]}]},{"name":"Shantou Science and Technology Project-Medical Treatment and Public Health Category","award":["2017A030313847"],"award-info":[{"award-number":["2017A030313847"]}]},{"name":"Shantou Science and Technology Project-Medical Treatment and Public Health Category","award":["81402116"],"award-info":[{"award-number":["81402116"]}]},{"name":"Shantou Science and Technology Project-Medical Treatment and Public Health Category","award":["A2018053"],"award-info":[{"award-number":["A2018053"]}]},{"name":"Shantou Science and Technology Project-Medical Treatment and Public Health Category","award":["180709154010294"],"award-info":[{"award-number":["180709154010294"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,7,21]]},"abstract":"<jats:p>\n                    Vasculogenic mimicry (VM), the novel approach for tumor cells to obtain blood supply, was reported to be involved in antiangiogenic resistance and poor prognosis in renal cell carcinoma (RCC). However, the molecular mechanisms underlying VM formed by RCC cells are still not clearly depicted. In the present study, we found that OS-RC-2 acquired the VM forming ability accompanied with the increased expressions of Vimentin and AXL and decreased expression of E-Cadherin by CoCl\n                    <jats:sub>2<\/jats:sub>\n                    treatment. Downregulation of Vimentin by siRNA severely impaired the capability of OS-RC-2 and 786-O to form VM structures induced by cell hypoxia in vitro. Moreover, knockdown of Vimentin inhibited cell migration and invasion, which could be prompted by hypoxia induction in RCC cells. In our clear cell RCC tissues, we found that VM was positively correlated with Vimentin overexpression and both predicted poor prognosis. In conclusion, Vimentin plays an important role in hypoxia induced VM formation of RCC cells and targeted Vimentin might be beneficial for RCC therapy.\n                  <\/jats:p>","DOI":"10.1155\/2019\/7259691","type":"journal-article","created":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T19:31:00Z","timestamp":1563737460000},"page":"1-12","source":"Crossref","is-referenced-by-count":10,"title":["Vimentin Overexpressions Induced by Cell Hypoxia Promote Vasculogenic Mimicry by Renal Cell Carcinoma Cells"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-4585","authenticated-orcid":true,"given":"Hao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkai","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Shantou University Medical College, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopeng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Shantou University Medical College, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4797"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.004"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.82"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.9"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.260"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3965"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0907"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.011"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.503"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-31-16"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.07.013"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9542"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nrc822"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12851"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1854-y"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.12.014"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.02.034"},{"key":"19","year":"2009"},{"key":"20","first-page":"12","year":"2004","journal-title":"IARC"},{"key":"21","first-page":"987","year":"1997","journal-title":"Cancer"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.12.007"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4405"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000163362.78475.63"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-9-9"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9055-1"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-008-9107-3"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1092"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.03.010"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0977"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.05.040"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13455"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0533-1"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.03.040"},{"key":"35","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(94)90553-3","volume":"79","year":"1994","journal-title":"Cell"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64120-X"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010105"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1309"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.509"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.05.010"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28151"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-014-1199-1"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/7259691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/7259691.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/7259691.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T01:33:18Z","timestamp":1569979998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/7259691\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,21]]},"references-count":42,"alternative-id":["7259691","7259691"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7259691","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,21]]}}}