{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:59:59Z","timestamp":1762869599812,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2019,10,9]]},"abstract":"<jats:p>Idiopathic nephrotic syndrome (INS) represents 15%\u201330% of adulthood glomerulopathies. Corticosteroids have been the main treatment for decades and are effective in 70% of minimal-change disease patients and ~30% of focal segmental glomerulosclerosis patients. Multidrug-resistant (steroids, calcineurin-inhibitors, cyclophosphamide, mycophenolate-mofetil, rituximab) idiopathic nephrotic syndrome is a major therapeutic challenge in nephrology. Apheresis (double-filtration plasmapheresis or semi specific immunoadsorption) could act by eliminating the circulating factor (apolipoproteinA1b, solubleCD40L, suPAR) increasing glomerular permeability seen in INS. The aim of the study was to report the outcome of three patients with multidrug-resistant INS treated successfully with apheresis.<\/jats:p>","DOI":"10.1155\/2019\/7304786","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T19:34:14Z","timestamp":1570649654000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series"],"prefix":"10.1155","volume":"2019","author":[{"given":"Hamza","family":"Naciri Bennani","sequence":"first","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00e9modialyse, Aph\u00e9r\u00e8ses et Transplantation R\u00e9nale, CHU Grenoble-Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jouve","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00e9modialyse, Aph\u00e9r\u00e8ses et Transplantation R\u00e9nale, CHU Grenoble-Alpes, Grenoble, France"},{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Noble","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00e9modialyse, Aph\u00e9r\u00e8ses et Transplantation R\u00e9nale, CHU Grenoble-Alpes, Grenoble, France"},{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5130-7286","authenticated-orcid":true,"given":"Lionel","family":"Rostaing","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00e9modialyse, Aph\u00e9r\u00e8ses et Transplantation R\u00e9nale, CHU Grenoble-Alpes, Grenoble, France"},{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Malvezzi","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00e9modialyse, Aph\u00e9r\u00e8ses et Transplantation R\u00e9nale, CHU Grenoble-Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Tetaz","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00e9modialyse, Aph\u00e9r\u00e8ses et Transplantation R\u00e9nale, CHU Grenoble-Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20082410853"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070734"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012040389"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01920219"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008538"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.12.014"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01462.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0930-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000437338"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-018-4061-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14582"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/7304786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/7304786.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2019\/7304786.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T19:34:15Z","timestamp":1570649655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crin\/2019\/7304786\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,9]]},"references-count":11,"alternative-id":["7304786","7304786"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7304786","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"type":"print","value":"2090-6641"},{"type":"electronic","value":"2090-665X"}],"subject":[],"published":{"date-parts":[[2019,10,9]]}}}