{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:05:36Z","timestamp":1784797536994,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2017SCU12037"],"award-info":[{"award-number":["2017SCU12037"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2017TD0004"],"award-info":[{"award-number":["2017TD0004"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012556","name":"Sichuan Youth Science and Technology Foundation","doi-asserted-by":"publisher","award":["2017SCU12037"],"award-info":[{"award-number":["2017SCU12037"]}],"id":[{"id":"10.13039\/100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012556","name":"Sichuan Youth Science and Technology Foundation","doi-asserted-by":"publisher","award":["2017TD0004"],"award-info":[{"award-number":["2017TD0004"]}],"id":[{"id":"10.13039\/100012556","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2019,11,3]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. We aimed to assess the procedural and clinical results of transcatheter aortic valve replacement (TAVR) for nonraphe bicuspid aortic stenosis (AS) with coronary vs mixed cusp fusion. <jats:italic>Background<\/jats:italic>. It remains unclear whether cusp fusion morphology affects TAVR outcomes in patients with nonraphe bicuspid AS. <jats:italic>Methods<\/jats:italic>. This retrospective study enrolled consecutive patients with severe symptomatic AS and type-0 bicuspid aortic valve, who underwent TAVR at our institution between 2012 and 2017. TAVR outcomes were defined based on the Valve Academic Research Consortium-2 recommendations. <jats:italic>Results<\/jats:italic>. Compared to patients with mixed cusp fusion (44\/71), those with coronary cusp fusion (27\/71) had a larger ellipticity index for the aortic annulus (21.9%\u2009\u00b1\u20099.0% vs 15.6%\u2009\u00b1\u20099.3%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:mrow><\/mml:math>) and increased left ventricular outflow tract obstruction (31.1%\u2009\u00b1\u20099.4% vs 26.9%\u2009\u00b1\u20097.5%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:mrow><\/mml:math>) but comparable rates of second valve implantation (15.9% vs 14.8%), mild paravalvular leakage (PVL, 38.5% vs 30.2%), permanent pacemaker implantation (PPM, 25.9% vs 15.9%), and 30-day mortality (7.4% vs 6.8%). Use of a first-generation transcatheter heart valve was associated with higher risk for mild PVL (odds ratio (OR)\u2009=\u20094.37; 95% confidence interval (95% CI)\u2009=\u20091.14\u201316.75; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:mrow><\/mml:math>) but not PPM (OR\u2009=\u20090.77; 95% CI\u2009=\u20090.22\u20132.62; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.67<\/mml:mn><\/mml:mrow><\/mml:math>), whereas a larger oversizing ratio tended to be associated with a higher PPM rate (OR\u2009=\u20091.49; 95% CI\u2009=\u20090.46\u20134.86; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.51<\/mml:mn><\/mml:mrow><\/mml:math>) but lower incidence of mild PVL (OR\u2009=\u20090.51; 95% CI\u2009=\u20090.19\u20131.35; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.17<\/mml:mn><\/mml:mrow><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. In AS patients with type-0 bicuspid valves, cusp fusion morphology does not affect the procedural or clinical results of TAVR. Use of second-generation transcatheter heart valves may provide more favorable results in such patients. This trial is registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/show\/NCT01683474\">NCT01683474<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2019\/7348964","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T18:33:10Z","timestamp":1572805990000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Transcatheter Aortic Valve Replacement in Patients with Aortic Stenosis Having Coronary Cusp Fusion versus Mixed Cusp Fusion Nonraphe Bicuspid Aortic Valve"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-3503","authenticated-orcid":true,"given":"Wen-hua","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-biao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-weixiang","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiay-yu","family":"Tsauo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu 610041, 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