{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:47:38Z","timestamp":1770058058989,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Academic Backbone Fund of Heilongjiang Province Education Department","award":["1253G053"],"award-info":[{"award-number":["1253G053"]}]},{"name":"Youth Academic Backbone Fund of Heilongjiang Province Education Department","award":["LBH-Q12009"],"award-info":[{"award-number":["LBH-Q12009"]}]},{"name":"Youth Academic Backbone Fund of Heilongjiang Province Education Department","award":["ZQG-034"],"award-info":[{"award-number":["ZQG-034"]}]},{"name":"Youth Academic Backbone Fund of Heilongjiang Province Education Department","award":["B201102"],"award-info":[{"award-number":["B201102"]}]},{"name":"Youth Academic Backbone Fund of Heilongjiang Province Education Department","award":["Z2010021"],"award-info":[{"award-number":["Z2010021"]}]},{"name":"Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province","award":["1253G053"],"award-info":[{"award-number":["1253G053"]}]},{"name":"Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province","award":["LBH-Q12009"],"award-info":[{"award-number":["LBH-Q12009"]}]},{"name":"Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province","award":["ZQG-034"],"award-info":[{"award-number":["ZQG-034"]}]},{"name":"Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province","award":["B201102"],"award-info":[{"award-number":["B201102"]}]},{"name":"Postdoctoral Science-Research Developmental Foundation of Heilongjiang Province","award":["Z2010021"],"award-info":[{"award-number":["Z2010021"]}]},{"name":"Youth Science and Technology Project of Traditional Chinese Medicine Department of Heilongjiang Province","award":["1253G053"],"award-info":[{"award-number":["1253G053"]}]},{"name":"Youth Science and Technology Project of Traditional Chinese Medicine Department of Heilongjiang Province","award":["LBH-Q12009"],"award-info":[{"award-number":["LBH-Q12009"]}]},{"name":"Youth Science and Technology Project of Traditional Chinese Medicine Department of Heilongjiang Province","award":["ZQG-034"],"award-info":[{"award-number":["ZQG-034"]}]},{"name":"Youth Science and Technology Project of Traditional Chinese Medicine Department of Heilongjiang Province","award":["B201102"],"award-info":[{"award-number":["B201102"]}]},{"name":"Youth Science and Technology Project of Traditional Chinese Medicine Department of Heilongjiang Province","award":["Z2010021"],"award-info":[{"award-number":["Z2010021"]}]},{"name":"Doctor Innovation Fund of Heilongjiang University of Chinese Medicine","award":["1253G053"],"award-info":[{"award-number":["1253G053"]}]},{"name":"Doctor Innovation Fund of Heilongjiang University of Chinese Medicine","award":["LBH-Q12009"],"award-info":[{"award-number":["LBH-Q12009"]}]},{"name":"Doctor Innovation Fund of Heilongjiang University of Chinese Medicine","award":["ZQG-034"],"award-info":[{"award-number":["ZQG-034"]}]},{"name":"Doctor Innovation Fund of Heilongjiang University of Chinese Medicine","award":["B201102"],"award-info":[{"award-number":["B201102"]}]},{"name":"Doctor Innovation Fund of Heilongjiang University of Chinese Medicine","award":["Z2010021"],"award-info":[{"award-number":["Z2010021"]}]},{"name":"Research Fund for Outstanding Young Teachers of Heilongjiang University of Chinese Medicine, National Education Department \u201cChunHui Plan\u201d Research Projects","award":["1253G053"],"award-info":[{"award-number":["1253G053"]}]},{"name":"Research Fund for Outstanding Young Teachers of Heilongjiang University of Chinese Medicine, National Education Department \u201cChunHui Plan\u201d Research Projects","award":["LBH-Q12009"],"award-info":[{"award-number":["LBH-Q12009"]}]},{"name":"Research Fund for Outstanding Young Teachers of Heilongjiang University of Chinese Medicine, National Education Department \u201cChunHui Plan\u201d Research Projects","award":["ZQG-034"],"award-info":[{"award-number":["ZQG-034"]}]},{"name":"Research Fund for Outstanding Young Teachers of Heilongjiang University of Chinese Medicine, National Education Department \u201cChunHui Plan\u201d Research Projects","award":["B201102"],"award-info":[{"award-number":["B201102"]}]},{"name":"Research Fund for Outstanding Young Teachers of Heilongjiang University of Chinese Medicine, National Education Department \u201cChunHui Plan\u201d Research Projects","award":["Z2010021"],"award-info":[{"award-number":["Z2010021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,1,3]]},"abstract":"<jats:p>Jinlingzi powder comprises<jats:italic> Melia toosendan Sieb. et Zucc<\/jats:italic>. and<jats:italic> Corydalis yanhusuo (Y.H. Chou &amp; Chun C.Hsu) W.T. Wang ex Z.Y. Su &amp; C.Y. Wu<\/jats:italic> and is usually applied in clinic as traditional Chinese medicine for pain. The present study aims to investigate the therapeutic actions of Jinlingzi powder and its extracted components and theirs treatment mechanism on the acetic acid induced-gastric ulcer in rats. The gastric ulcer model was induced by the administration of acetic acid in rats (84 male). Jinlingzi powder water decoction, its polysaccharide, and nonalkaloid and alkaloid components were used to investigate the therapeutic actions on the acetic acid induced-gastric ulcer by measuring the related pharmacy and pharmacodynamic factors, including ulcer index, ulcer area, ulcer healing rate, interleukin-8 (IL-8), tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic> (TNF-<jats:italic>\u03b1<\/jats:italic>), neurotensin (NT), platelet activating factor (PAF), thromboxane B2 (TXB2), and vascular endothelial growth factor (VEGF) in rat serum, acetylcholinesterase (AChE) in brain tissue, prostaglandin E2 (PGE2), and basic fibroblast growth factor (bFGF) in gastric tissue. Among the various groups, Jinlingzi powder and the nonalkaloid components caused significant changes in IL-8, TNF-<jats:italic>\u03b1<\/jats:italic>, NT, PAF TXB2, and VEGF values in the serum. The AChE content in the rats\u2019 brain tissue was also reduced after using Jinlingzi powder and the nonalkaloid components. Additionally, Jinlingzi powder and the nonalkaloid components considerably affect the amount of PGE2 and bFGF in a rat\u2019s stomach tissue. Therefore, Jinlingzi powder and the nonalkaloid components can effectively inhibit neutral neutrophil activation, prevent capillaries thrombosis, and protect gastric mucosa. Thus, the nonalkaloid components of the Jinlingzi powder play a key role in the treatment of gastric ulcer.<\/jats:p>","DOI":"10.1155\/2019\/7365841","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T18:32:28Z","timestamp":1546540348000},"page":"1-12","source":"Crossref","is-referenced-by-count":11,"title":["Treatment Effects of Jinlingzi Powder and Its Extractive Components on Gastric Ulcer Induced by Acetic Acid in Rats"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-8362","authenticated-orcid":true,"given":"Xueying","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin, 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin, 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghai","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin, 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin, 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7624-0981","authenticated-orcid":true,"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin, 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-016-0985-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2010.0706"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.17020"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.10.066"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9075-7"},{"key":"6","first-page":"259","volume":"56","year":"2005","journal-title":"Journal of Physiology and Pharmacology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90773-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(00)00146-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02285191"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00627.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.125"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.07.031"},{"issue":"6","key":"13","first-page":"270","volume":"3","year":"2009","journal-title":"Pharmacognosy Reviews"},{"key":"14","first-page":"12","volume":"15","year":"2002","journal-title":"Gansu Journal of Traditional Chinese Medicine"},{"key":"15","first-page":"34","volume":"32","year":"2008","journal-title":"Journal of Practical Traditional Chinese Internal Medicine"},{"key":"16","first-page":"1179","volume":"30","year":"2011","journal-title":"Herald of Medicine"},{"key":"17","first-page":"1578","volume":"33","year":"2011","journal-title":"Chinese Traditional Patent Medicine"},{"key":"18","first-page":"111","volume":"22","year":"2016","journal-title":"Guiding Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"19","first-page":"28","volume":"28","year":"2011","journal-title":"Information on Traditional Chinese Medicine"},{"key":"20","first-page":"61","volume":"40","year":"2012","journal-title":"Acta Chinese Medicine and Pharmacology"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/bf02235252"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.09.006"},{"key":"23","first-page":"353","volume":"15","year":"2004","journal-title":"European Network"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh349"},{"key":"25","first-page":"1009","volume":"143","year":"1993","journal-title":"The American Journal of Pathology"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2174\/1568026043451609"},{"key":"27","first-page":"34","volume":"11","year":"2006","journal-title":"Chinese Journal of Gastroenterology"},{"key":"28","first-page":"134","volume":"116","year":"1994","journal-title":"Surgery"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-016-1057-2"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1163\/156856003322315587"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.79.101"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01081-9"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.21.335"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70218-1"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00127.2013"},{"key":"36","doi-asserted-by":"crossref","first-page":"e58671","DOI":"10.1371\/journal.pone.0058671","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i32.5887"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007070"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/7365841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/7365841.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/7365841.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T18:32:37Z","timestamp":1546540357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2019\/7365841\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,3]]},"references-count":38,"alternative-id":["7365841","7365841"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7365841","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,3]]}}}