{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:20:35Z","timestamp":1792628435118,"version":"4.5.0"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Analytical Chemistry"],"published-print":{"date-parts":[[2019,3,26]]},"abstract":"<jats:p>\n                    Herein, the main objective of this research is to design and synthesize a novel optical chemosensor, 2,6-Bis(4-dimethylaminophenyl)-4-(dicyanomethylene)-cyclohexane-1,1-dicarbo-nitrile (BDC), for detection of one of the most significant metal ions Cu(II). This novel fluorescent chemosensor exhibits unique optical properties with large Stokes shift (about 170 nm) approximately. The fluorescence and UV\u2013vis absorption performance among the BDC probe and Cu(II) ions were examined in 1:9 (v\/v) methanol\u2013HEPES buffer (pH = 7.2) solution. Also, BDC displays high selectivity for Cu(II) concerning other cations. Moreover, this probe provides high selectivity and sensitivity based on their fluorescence properties and recognition abilities within a detection limit of the Cu(II) contents (LOD 2.3 x 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    M). The suggested mechanism of BDC sensor is attributed to the chelation process with Cu(II), to establish a 1:1 metal-ligand ratio complex with a binding constant (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:msub>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">K<\/mml:mi>\n                          <\/mml:mrow>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">b<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">i<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">n<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">d<\/mml:mi>\n                          <\/mml:mrow>\n                        <\/mml:msub>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    = 7.16 x 10\n                    <jats:sup>4<\/jats:sup>\n                    M\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). The detection process is accompanied by quenching the main emission peak of the BDC at 571 nm. All the experimental data were collected to investigate the effects of several important parameters such as reversibility and the concentration limits. Besides, we study the interference of various metal ions on selectivity and detection capacity of this significant Cu (II) ion. This novel chemosensor shows ultrasensitive, fast tracing of Cu(II) in the physiological pH range (pH 7.2) and therefore may propose a novel promising method for the investigation of the biological functions of Cu(II) in living cells.\n                  <\/jats:p>","DOI":"10.1155\/2019\/7381046","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T19:38:22Z","timestamp":1553629102000},"page":"1-8","source":"Crossref","is-referenced-by-count":27,"title":["Ultrasensitive Optical Chemosensor for Cu(II) Detection"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-0439","authenticated-orcid":true,"given":"Sayed M.","family":"Saleh","sequence":"first","affiliation":[{"name":"Chemistry Department, Science College, Qassim University, Buraidah, Saudi Arabia"},{"name":"Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham","family":"Ali","sequence":"additional","affiliation":[{"name":"Chemistry Department, Science College, Qassim University, Buraidah, Saudi Arabia"},{"name":"Chemistry Department, Science College, Suez University, Suez, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Alminderej","sequence":"additional","affiliation":[{"name":"Chemistry Department, Science College, Qassim University, Buraidah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A. I.","family":"Ali","sequence":"additional","affiliation":[{"name":"Chemistry Department, Science College, Suez Canal University, Ismailia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1021\/jo052542a"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/109374001753146207"},{"key":"3","first-page":"12","volume-title":"Metal ions in biological systems","year":"1981"},{"key":"4","year":"1997"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(99)00066-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)01714-7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(02)00298-3"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200300841"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1021\/cr040410w"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R000006200"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1021\/ic401865e"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1330"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.01.047"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1021\/ol7022714"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.013"},{"issue":"6","key":"16","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1021\/acschembio.7b00170","volume":"12","year":"2017","journal-title":"ACS Chemical Biology"},{"key":"17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.aquatox.2017.09.007","volume":"192","year":"2017","journal-title":"Aquatic Toxicology"},{"key":"18","volume":"2015","year":"2015","journal-title":"International Journal of Analytical Chemistry"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1727126"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2018.01.058"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2015.07.029"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.synthmet.2016.09.011"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-015-1713-z"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2015.10.027"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201105228"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1021\/ja412380j"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/BF01242319"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2005.10.055"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1039\/b501536g"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4005(03)00033-9"},{"key":"31a","doi-asserted-by":"publisher","DOI":"10.1021\/jo3014319"},{"key":"31b","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.06.016"},{"key":"32","doi-asserted-by":"crossref","first-page":"68709","DOI":"10.1039\/C6RA12750A","volume":"6","year":"2016","journal-title":"RSC Advances"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201105459"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1021\/ja039073j"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1021\/ja055064u"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1021\/ja031839s"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2015.04.072"},{"key":"38a","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2012.09.019"},{"key":"38b","doi-asserted-by":"publisher","DOI":"10.1021\/ol101535s"},{"key":"38c","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.snb.2011.01.066","volume":"156","year":"2011","journal-title":"Sensors and Actuators B: Chemical"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2014.12.055"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200900475"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1021\/ol100381g"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1021\/ol900050z"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2011.06.041"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1021\/ar9601555"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1021\/ol0504648"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA18097C"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2017.04.019"},{"key":"48","volume":"6, article 28972","year":"2016","journal-title":"Scientific Reports - Nature"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2007.07.119"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-015-2343-4"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.08.067"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2012.07.102"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2015.03.109"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1021\/om3004459"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1021\/ic102430a"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b08539"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2014.05.033"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2015.04.111"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1021\/ac00243a033"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1021\/es051687w"}],"container-title":["International Journal of Analytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijac\/2019\/7381046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijac\/2019\/7381046.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijac\/2019\/7381046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T19:38:25Z","timestamp":1553629105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijac\/2019\/7381046\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,26]]},"references-count":63,"alternative-id":["7381046","7381046"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7381046","relation":{},"ISSN":["1687-8760","1687-8779"],"issn-type":[{"value":"1687-8760","type":"print"},{"value":"1687-8779","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,26]]}}}