{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:18:16Z","timestamp":1770455896040,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T00:00:00Z","timestamp":1575676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,12,7]]},"abstract":"<jats:p>The presence of <jats:italic>KMT2A\/AFF1<\/jats:italic> rearrangement in B-lymphoblastic leukemia (B-ALL) is an independent poor prognostic factor and has been associated with higher rate of treatment failure and higher risk of linage switch under therapy. Blinatumomab has shown promising therapeutic results in refractory or relapsed B-ALL; however, it has potential risk of inducing lineage switch, especially in <jats:italic>KMT2A\/AFF1<\/jats:italic> rearranged B-ALL into acute myeloid leukemia and\/or myeloid sarcoma. We report a 40-year-old female with <jats:italic>KMT2A\/AFF1<\/jats:italic>-rearranged B-ALL that was refractory to conventional chemotherapy. Following administration of blinatumomab, she developed a breast mass proven to be myeloid sarcoma, in addition to bone marrow involvement by AML. Approximately six weeks after cessation of blinatumomab, a repeat bone marrow examination revealed B\/myeloid MPAL.<\/jats:p>","DOI":"10.1155\/2019\/7394619","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T18:30:48Z","timestamp":1575743448000},"page":"1-4","source":"Crossref","is-referenced-by-count":13,"title":["Immunotherapy- (Blinatumomab-) Related Lineage Switch of <i>KMT2A\/AFF1<\/i> Rearranged B-Lymphoblastic Leukemia into Acute Myeloid Leukemia\/Myeloid Sarcoma and Subsequently into B\/Myeloid Mixed Phenotype Acute Leukemia"],"prefix":"10.1155","volume":"2019","author":[{"given":"Rui R.","family":"He","sequence":"first","affiliation":[{"name":"Department of Pathology, Inova Fairfax Hospital, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zacharia","family":"Nayer","sequence":"additional","affiliation":[{"name":"School of Medicine, George Washington University, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hogan","sequence":"additional","affiliation":[{"name":"School of Medicine, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund S.","family":"Cuevo","sequence":"additional","affiliation":[{"name":"Inova Schar Cancer Institute, Inova Fairfax Hospital, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Woodward","sequence":"additional","affiliation":[{"name":"Department of Pathology, Inova Fairfax Hospital, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Heyer","sequence":"additional","affiliation":[{"name":"Inova Schar Cancer Institute, Inova Fairfax Hospital, Falls Church, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics, Quest Diagnostics Nichols Institute, Chantilly, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-8000","authenticated-orcid":true,"given":"Jess F.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-665547"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(16)30580-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018018093"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1562185"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.89"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25953"},{"key":"7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/leu.2017.213","volume":"32","year":"2018","journal-title":"Leukemia"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23266"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12320"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.18"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00004"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.04.020"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(92)90153-x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3050-6"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/7394619.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/7394619.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/7394619.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T18:31:55Z","timestamp":1576866715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/7394619\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,7]]},"references-count":14,"alternative-id":["7394619","7394619"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7394619","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,7]]}}}