{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:35:19Z","timestamp":1761824119112,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["134487","PIBB17-2"],"award-info":[{"award-number":["134487","PIBB17-2"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UAA","award":["134487","PIBB17-2"],"award-info":[{"award-number":["134487","PIBB17-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:p>Amoebic liver abscess (ALA) is the most common extraintestinal amoebiasis caused by <jats:italic>Entamoeba histolytica<\/jats:italic> (<jats:italic>E. histolytica<\/jats:italic>). However, despite current knowledge and scientific advances about this infection, there are no effective treatments to prevent it. Herein, the antiamoebic capacity of curcumin in a hamster model was evaluated. Curcumin (150\u2009mg\/kg, p.o., daily during 10 days before infection) considerably prevents liver damage induced at 12 and 48\u2009h post-intrahepatic inoculation of trophozoites and decreases ALT, ALP, and <jats:italic>\u03b3<\/jats:italic>-GTP activities, and macroscopic and microscopic observations were consistent with these results. On the other hand, after one week of intraportal inoculation, liver damage was prevented by curcumin (150\u2009mg\/kg, p.o., daily, 20 days before amoebic inoculation and during the week of infection); liver\/body weight ratios and tissue and histological stains showed normal appearance; in addition, the increases in ALT, ALP, and <jats:italic>\u03b3<\/jats:italic>-GTP activities were prevented; the depletion of glycogen content induced by the amoebic damage was partially but significantly prevented, while NF-<jats:italic>\u03ba<\/jats:italic>B activity was inhibited and the expression of IL-1<jats:italic>\u03b2<\/jats:italic> was reduced; Nrf2 production showed a tendency to increase it, and HO-1 protein was overexpressed. These results suggest for the first time that curcumin can be a compound with antiamoebic effect in the liver, suggesting that its daily use could help greatly decrease the incidence of this type of infection.<\/jats:p>","DOI":"10.1155\/2019\/7431652","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T19:36:41Z","timestamp":1555357001000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["Curcumin Provides Hepatoprotection against Amoebic Liver Abscess Induced by <i>Entamoeba histolytica<\/i> in Hamster: Involvement of Nrf2\/HO-1 and NF-<i>\u03ba<\/i>B\/IL-1<i>\u03b2<\/i> Signaling Pathways"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-2494","authenticated-orcid":true,"given":"Jos\u00e9 Roberto","family":"Mac\u00edas-P\u00e9rez","sequence":"first","affiliation":[{"name":"Qu\u00edmica Cl\u00ednica, Unidad Acad\u00e9mica Multidisciplinaria Zona Huasteca, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Ciudad Valles, SLP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-662X","authenticated-orcid":true,"given":"Liseth Rub\u00ed","family":"Aldaba-Muruato","sequence":"additional","affiliation":[{"name":"Qu\u00edmica Cl\u00ednica, Unidad Acad\u00e9mica Multidisciplinaria Zona Huasteca, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Ciudad Valles, SLP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Luz","family":"Mart\u00ednez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda, Centro de Ciencias B\u00e1sicas, Universidad Aut\u00f3noma de Aguascalientes, Aguascalientes, Ags, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-6919","authenticated-orcid":true,"given":"Mart\u00edn Humberto","family":"Mu\u00f1oz-Ortega","sequence":"additional","affiliation":[{"name":"Departamento 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