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Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes. <jats:italic>Methods<\/jats:italic>. Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996\u20132003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. <jats:italic>Results<\/jats:italic>. MPO correlated positively with MMP-8 (rho 0.496, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and MMP-9 (rho 0.153, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>) but negatively with TIMP-1 (rho -0.361, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). MMP-8 emerged as the best predictor of disease outcomes: a CSF MMP-8 concentration above the median increased the odds of death 4.9-fold (95% confidence interval 1.8\u201312.9). <jats:italic>Conclusions<\/jats:italic>. CSF MMP-8 presented as an attractive prognostic marker in children with bacterial meningitis.<\/jats:p>","DOI":"10.1155\/2019\/7436932","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T18:33:12Z","timestamp":1572805992000},"page":"1-8","source":"Crossref","is-referenced-by-count":14,"title":["The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-8276","authenticated-orcid":true,"given":"Okko","family":"Savonius","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmeli","family":"Roine","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Diego Portales, Santiago, 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