{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:21:06Z","timestamp":1781191266974,"version":"3.54.1"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602419"],"award-info":[{"award-number":["81602419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570568"],"award-info":[{"award-number":["81570568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602419"],"award-info":[{"award-number":["81602419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570568"],"award-info":[{"award-number":["81570568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,12,16]]},"abstract":"<jats:p>Liver ischemia\/reperfusion (IR) injury is a severe complication of liver surgery. Moreover, nonalcoholic fatty liver disease (NAFLD) patients are particularly vulnerable to IR injury, with higher rates of postoperative morbidity and mortality after liver surgeries. Our previous study found that renalase (RNLS) was highly sensitive and responsive to oxidative stress, which may be a promising biomarker for the evaluation of the severity of liver IR injury. However, the role of RNLS in liver IR injury remains unclear. In the present study, we intensively explored the role and mechanism of RNLS in fatty liver IR injury in vivo and in vitro. C57BL\/6 mice were divided into 2 groups feeding with high-fat diet (HFD) and control diet (CD), respectively. After 20 weeks\u2019 feeding, they were suffered from portal triad blockage and reflow to induce liver IR injury. Additionally, oleic acid (OA) and <jats:italic>tert<\/jats:italic>-butyl hydroperoxide (t-BHP) were used in vitro to induce steatotic hepatocytes and to simulate ROS burst and mimic cellular oxidative stress following portal triad blockage and reflow, respectively. Our data showed that RNLS was downregulated in fatty livers, and RNLS administration effectively attenuated IR injury by reducing ROS production and improving mitochondrial function through activating SIRT1. Additionally, the downregulation of RNLS in the fatty liver was mediated by a decrease of signal transduction and activator of transcription 3 (STAT3) expression under HFD conditions. These findings make RNLS a promising therapeutic strategy for the attenuation of liver IR injury.<\/jats:p>","DOI":"10.1155\/2019\/7534285","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T18:31:43Z","timestamp":1576521103000},"page":"1-21","source":"Crossref","is-referenced-by-count":35,"title":["Renalase Attenuates Mouse Fatty Liver Ischemia\/Reperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-3436","authenticated-orcid":true,"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-5867","authenticated-orcid":true,"given":"Jian","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1821-6147","authenticated-orcid":true,"given":"Jianrong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-1122","authenticated-orcid":true,"given":"Huili","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-637X","authenticated-orcid":true,"given":"Jiliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2304-3881.2015.07.05"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4800(03)00008-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70032-4"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4596"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5486"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0736-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2013.811721"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.020"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24066"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000044"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu255"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/000368497"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012090943"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3178562"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1021\/ja407384h"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.03.015"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.12.001"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12016"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7594"},{"issue":"1","key":"21","first-page":"279","volume":"41","year":"2019","journal-title":"Oncology Reports"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000312"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1355"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.7150\/jca.29490"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27695"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.906610"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.08.002"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28245"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.488"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.07.002"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1021\/bi500798n"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.05.002"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70599-2"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.10.001"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.03.004"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12450"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.05.005"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00187-5"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.02.011"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.2008038"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.023"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21405"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16098020"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000643"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2256"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(92)90182-G"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.2174\/092986711795656081"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90116-0"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.47.120505.105122"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s10541-005-0102-7"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00362.2007"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.048405"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105011"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.12.001"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6706-0_8"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00055-7"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0593-y"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2018.1492766"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27308"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.01.005"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040403"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.06.029"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2016.1153067"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0355-2"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12491"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00176"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2015.05.002"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25658-4"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-015-0486-5"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.03.032"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126296"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-018-0698-8"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1154-0"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24517"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/7534285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/7534285.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/7534285.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T18:31:47Z","timestamp":1576521107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2019\/7534285\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":75,"alternative-id":["7534285","7534285"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7534285","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,16]]}}}