{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:07:17Z","timestamp":1791389237307,"version":"4.3.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2019,3,18]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To study the clinical significance of the Graves\u2019 orbitopathy-specific quality of life (GO-QOL) questionnaire in mainland Chinese patients. <jats:italic>Methods<\/jats:italic>. A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from April 2017 to April 2018. Eighty-eight consecutive Graves\u2019 orbitopathy (GO) patients completed the two subscales of the GO-QOL questionnaire: visual functioning and appearance. The disease severity of GO was measured by the European Group on Graves\u2019 Orbitopathy (EUGOGO) classification, and clinical activity was evaluated by the clinical activity score (CAS). <jats:italic>Results<\/jats:italic>. The mean scores of GO-QOL questionnaire for the visual functioning and appearance subscales were 68.4\u2009\u00b1\u200931.2 and 62.0\u2009\u00b1\u200927.4, respectively. Lower QOL scores for the visual functioning subscale were significantly correlated with disease severity, the CAS and diplopia (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Lower QOL scores for appearance were significantly correlated with the CAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Although no correlation was found between the appearance subscale scores and disease severity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.407<\/mml:mn><\/mml:mrow><\/mml:math>), a downward trend in the appearance subscale scores as the severity of GO increased from mild to sight-threatening GO was found. <jats:italic>Conclusion<\/jats:italic>. A strong correlation between disease severity and clinical activity has been shown in the GO-QOL questionnaire, suggested by the EUGOGO. The GO-QOL questionnaire is a simple and effective appraisal instrument in the evaluation of health-related QOL in the mainland Chinese patients with GO.<\/jats:p>","DOI":"10.1155\/2019\/7602419","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T19:36:28Z","timestamp":1552937788000},"page":"1-5","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of the Graves\u2019 Orbitopathy-Specific Quality of Life Questionnaire in the Mainland Chinese Population"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6605-4736","authenticated-orcid":true,"given":"Peng","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-xian","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-6111","authenticated-orcid":true,"given":"Zi-jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-4064","authenticated-orcid":true,"given":"Yuan-yu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-9900","authenticated-orcid":true,"given":"Ming-tong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-8642","authenticated-orcid":true,"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.02.018"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176064"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2015.06.001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.10.005"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.12.012"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.7.773"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.359"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.12.002"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.88.1.75"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2018.1503693"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.75884"},{"issue":"2","key":"12","first-page":"86","volume":"58","year":"2010","journal-title":"The 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