{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:36:29Z","timestamp":1747190189503,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,8,27]]},"abstract":"<jats:p>Here, we describe a rare case of acquired von Willebrand syndrome (VWS) associated with intracranial plasmacytoma. The literature includes reports of a few cases of plasmacytoma with central nervous involvement, but none of them with acquired VWS. Diagnosis was made based on a stereotaxic intracerebral biopsy. During this biopsy, a ventriculoperitoneal shunt was established, which was complicated with abnormal bleeding. Subsequent hemostasis assessment related to hemopathy revealed acquired von Willebrand disease. The patient received induction therapy with bortezomib, thalidomide, and dexamethasone (VTD), followed by high-dose melphalan chemotherapy and autologous stem cell transplantation, and then VTD consolidation, and finally maintenance with lenalidomide. Our patient currently remains in very good partial response without neurological symptoms after 4\u2009months of maintenance. The patient is free of progression 14\u2009months after their original presentation.<\/jats:p>","DOI":"10.1155\/2019\/7609308","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T19:31:14Z","timestamp":1566934274000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-9172","authenticated-orcid":true,"given":"H.","family":"Auge","sequence":"first","affiliation":[{"name":"Hematology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Yguel","sequence":"additional","affiliation":[{"name":"Histopathology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, 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