{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:30:33Z","timestamp":1790523033554,"version":"4.1.0"},"reference-count":99,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","award":["18PTZWHZ00060"],"award-info":[{"award-number":["18PTZWHZ00060"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","award":["81870227"],"award-info":[{"award-number":["81870227"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["18PTZWHZ00060"],"award-info":[{"award-number":["18PTZWHZ00060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870227"],"award-info":[{"award-number":["81870227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2019,11,22]]},"abstract":"<jats:p>\n                    While the role of hyperhomocysteinemia in cardiovascular pathogenesis continuously draws attention, deficiency of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) has been growingly implicated in cardiovascular diseases. Generation of H\n                    <jats:sub>2<\/jats:sub>\n                    S is closely associated with the metabolism of homocysteine via key enzymes such as cystathionine\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -synthase (CBS) and cystathionine\n                    <jats:italic>\u03b3<\/jats:italic>\n                    -lyase (CSE). The level of homocysteine and H\n                    <jats:sub>2<\/jats:sub>\n                    S is regulated by each other. Metabolic switch in the activity of CBS and CSE may occur with a resultant operating preference change of these enzymes in homocysteine and H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism. This paper presented an overview regarding (1) linkage between the metabolism of homocysteine and H\n                    <jats:sub>2<\/jats:sub>\n                    S, (2) mutual regulation of homocysteine and H\n                    <jats:sub>2<\/jats:sub>\n                    S, (3) imbalance of homocysteine and H\n                    <jats:sub>2<\/jats:sub>\n                    S in cardiovascular disorders, (4) mechanisms underlying the protective effect of H\n                    <jats:sub>2<\/jats:sub>\n                    S against homocysteine-induced vascular injury, and (5) the current status of homocysteine-lowering and H\n                    <jats:sub>2<\/jats:sub>\n                    S-based therapies for cardiovascular disease. The metabolic imbalance of homocysteine and H\n                    <jats:sub>2<\/jats:sub>\n                    S renders H\n                    <jats:sub>2<\/jats:sub>\n                    S\/homocysteine ratio a potentially reliable biomarker for cardiovascular disease and development of drugs or interventions targeting the interplay between homocysteine and H\n                    <jats:sub>2<\/jats:sub>\n                    S to maintain the endogenous balance of these two molecules may hold an even bigger promise for management of vascular disorders than targeting homocysteine or H\n                    <jats:sub>2<\/jats:sub>\n                    S alone.\n                  <\/jats:p>","DOI":"10.1155\/2019\/7629673","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T18:30:50Z","timestamp":1574447450000},"page":"1-11","source":"Crossref","is-referenced-by-count":64,"title":["Imbalance of Homocysteine and H\n                    <sub>2<\/sub>\n                    S: Significance, Mechanisms, and Therapeutic Promise in Vascular Injury"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-4431","authenticated-orcid":true,"given":"Qin","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Basic Medical Research & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6497-876X","authenticated-orcid":true,"given":"Guo-Wei","family":"He","sequence":"additional","affiliation":[{"name":"Center for Basic Medical Research & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China"},{"name":"School of Pharmacy, Wannan Medical College, Wuhu, Anhui, China"},{"name":"Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.002758"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101733"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1061"},{"issue":"10","key":"4","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1681\/ASN.V12102181","volume":"12","year":"2001","journal-title":"Journal of the American Society of Nephrology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3391"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0510-x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6290931"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400481200"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808026200"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2253"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.02.004"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2371"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-012-1886-2"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp111"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-003-0050-x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.5.849"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2015.12.010"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/clinchem\/41.3.340","volume":"41","year":"1995","journal-title":"Clinical Chemistry"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.010868"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160612560"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.01.001"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9477-z"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1271-5"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309049110"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-21247"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0011-8"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2018.1431626"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1509211"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2073"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03776-9"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200703010-00008"},{"issue":"5","key":"33","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3760\/cma.j.issn.0366-6999.20132694","volume":"127","year":"2014","journal-title":"Chinese Medical Journal"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00624"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707243370403"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(97)00099-5"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002208"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4627391"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00329.2016"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13988"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00398.2011"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-38467-6"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-013-6478-5"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-018-0010-0"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.08.028"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05438.x"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00282.2016"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10562"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2017.04.007"},{"issue":"3","key":"51","first-page":"219","volume":"39","year":"2009","journal-title":"Annals of Clinical and Laboratory Science"},{"issue":"1","key":"52","first-page":"15","volume":"65","year":"2014","journal-title":"Journal of Physiology and Pharmacology"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.058"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24722"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.07.051"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27120"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1815fje"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3812568"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2012.752535"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S68415"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1089\/152308603768295113"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2016.05.008"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.022"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12101"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.09.021"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7004"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.197"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2898"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0501"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C116.742213"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.07.021"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17721"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.10.009"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1113\/JP270054"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1159\/000448712"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw104"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02401-7"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001669"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172455"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07391-2"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12017"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1553"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.03.032"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.7.795"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-015-0406-x"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd006612.pub5"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980014002134"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60872-6"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(12)70091-1"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310211"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-015-0235-8"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12967"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-018-4169-9"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001605"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2017.1313847"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7068"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00598"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.311134"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.07.042"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/7629673.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/7629673.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/7629673.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T12:22:43Z","timestamp":1722082963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2019\/7629673\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":99,"alternative-id":["7629673","7629673"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7629673","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]}}}