{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:04:15Z","timestamp":1792058655652,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2011\/13630-7"],"award-info":[{"award-number":["2011\/13630-7"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2012\/25237-0"],"award-info":[{"award-number":["2012\/25237-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2011\/13630-7"],"award-info":[{"award-number":["2011\/13630-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2012\/25237-0"],"award-info":[{"award-number":["2012\/25237-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/13630-7"],"award-info":[{"award-number":["2011\/13630-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/25237-0"],"award-info":[{"award-number":["2012\/25237-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/13630-7"],"award-info":[{"award-number":["2011\/13630-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/25237-0"],"award-info":[{"award-number":["2012\/25237-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Franca","award":["2011\/13630-7"],"award-info":[{"award-number":["2011\/13630-7"]}]},{"name":"University of Franca","award":["2012\/25237-0"],"award-info":[{"award-number":["2012\/25237-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2019,1,10]]},"abstract":"<jats:p>Trees of the<jats:italic> Copaifera<\/jats:italic> genus are native to the tropical regions of Latin America and Western Africa.<jats:italic> Copaifera<\/jats:italic> sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in<jats:italic> Copaifera<\/jats:italic> and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Bearing in mind the fact that the Ames test is an excellent tool to assess the safety of extracts, oils, and phytochemicals isolated from medicinal plants, from it, we evaluate the mutagenic potential of four species, between oleoresins (<jats:italic>C. oblongifolia<\/jats:italic>;<jats:italic> C. langsdorffii<\/jats:italic>) and leaves extracts (<jats:italic>C. lucens<\/jats:italic>;<jats:italic> C. multijuga<\/jats:italic>), of the<jats:italic> Copaifera<\/jats:italic> genus and also of kaurenoic acid, which is one of its major compounds. The results showed that the<jats:italic> Copaifera<\/jats:italic> spp. and kaurenoic acid did not induce an increase in the number of revertant colonies, without mutagenic effect in experiments, in the all concentrations evaluated by Ames test. The results obtained in our study support the safe use of the<jats:italic> Copaifera<\/jats:italic> genus medicinal plants selected and of kaurenoic acid.<\/jats:p>","DOI":"10.1155\/2019\/7631531","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T18:31:52Z","timestamp":1547145112000},"page":"1-9","source":"Crossref","is-referenced-by-count":12,"title":["Investigation of Safety Profile of Four<i> Copaifera<\/i> Species and of Kaurenoic Acid by<i> Salmonella<\/i>\/Microsome Test"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jaqueline Lopes","family":"Damasceno","sequence":"first","affiliation":[{"name":"Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadira Fern\u00e1ndez","family":"Arnet","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Capaldi","family":"Fortunato","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Health, University of Araraquara, Rua Carlos Gomes 1338, 14801-320 Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Girotto","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Health, University of Araraquara, Rua Carlos Gomes 1338, 14801-320 Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Davi","family":"Marena","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Health, University of Araraquara, Rua Carlos Gomes 1338, 14801-320 Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Patti","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Health, University of Araraquara, Rua Carlos Gomes 1338, 14801-320 Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Aparecida","family":"Resende","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Health, University of Araraquara, Rua Carlos Gomes 1338, 14801-320 Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Ricardo","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo C\u00e1ssio Sola","family":"Veneziani","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8641-9686","authenticated-orcid":true,"given":"Jairo Kenupp","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-6878","authenticated-orcid":true,"given":"Carlos Henrique Gomes","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"6","key":"1","first-page":"965","volume":"63","year":"1985","journal-title":"Bulletin of the World Health Organization"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1021\/np5000796"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.03.005"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17043866"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5992"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051511"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1295"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0961-4"},{"issue":"10","key":"10","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/cbdv.201600065","volume":"13","year":"2016","journal-title":"Chemistry & Biodiversity"},{"issue":"6","key":"11","first-page":"1106","volume":"28","year":"2017","journal-title":"Journal of the Brazilian Chemical Society"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2015.05.005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2017.1420505"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.12.035"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1043630"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000316"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-40422002000200016"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1021\/np200989t"},{"key":"19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.9734\/EJMP\/2014\/6926","volume":"4","year":"2014","journal-title":"European Journal of Medicinal Plants"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199908\/09)13:5<397::AID-PTR473>3.0.CO;2-#"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.10.001"},{"issue":"2","key":"22","first-page":"49","volume":"24","year":"2007","journal-title":"Tropical Biomedicine"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(83)90010-9"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(01)00153-X"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.085"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.12.026"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.12.5135"},{"key":"28","year":"2013"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/em.2850160502"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.04.002"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-015-1483-9"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(82)90026-7"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17055255"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2016.01.007"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.08.027"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2005.08.011"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.06.007"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21968"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(98)00159-4"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(00)00064-6"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(97)00020-3"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20121423"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2777"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.11.093"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-3"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.09.027"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.06.016"},{"issue":"1","key":"48","volume":"7","year":"2018","journal-title":"Antimicrobial Resistance and Infection Control"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572012005000052"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2010.04.008"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2011.03.010"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2009.06.002"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1038\/258121a0"},{"key":"54","first-page":"29","volume":"148","year":"1985","journal-title":"Mutation Research"},{"issue":"2","key":"55","first-page":"101","volume":"297","year":"1993","journal-title":"Mutation Research - Reviews in Mutation Research"},{"key":"56","first-page":"159","volume":"1","year":"2002","journal-title":"Genetics And Molecular Research"},{"key":"57","first-page":"439","volume":"17","year":"2008","journal-title":"Fresenius Environmental Bulletin"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00073-2"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2010.12.015"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2006.11.008"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.12.013"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.01.032"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/7631531.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/7631531.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2019\/7631531.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T18:31:57Z","timestamp":1547145117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2019\/7631531\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":62,"alternative-id":["7631531","7631531"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7631531","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,10]]}}}