{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:23:46Z","timestamp":1740173026966,"version":"3.37.3"},"reference-count":74,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carolinas Medical Center Trauma Center of Excellence"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2019,2,12]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. <jats:italic>Setting<\/jats:italic>. Hospital emergency department. <jats:italic>Participants<\/jats:italic>. 21 women ages 18-35 with TBI and 21 controls. <jats:italic>Design<\/jats:italic>. Repeated measures. <jats:italic>Main Measures<\/jats:italic>. Serum samples at baseline and 72 hours; immunoassays for estradiol (E2), progesterone (PRO), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and cortisol (CORT); and health history. <jats:italic>Results<\/jats:italic>. Women with TBI had lower E2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.042<\/mml:mn><\/mml:math>) and higher CORT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.028<\/mml:mn><\/mml:math>) levels over time. Lower Glasgow Coma Scale (GSC) and OCs were associated with lower FSH (GCS <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.021<\/mml:mn><\/mml:math>; OCs <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.016<\/mml:mn><\/mml:math>) and higher CORT (GCS <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>; OCs <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. Acute TBI may suppress E2 and increase CORT in young women. OCs appeared to independently affect CORT and FSH responses. Future work is needed with a larger sample to characterize TBI effects on women\u2019s endogenous hormone response to injury and OC use\u2019s effects on post-TBI stress response and gonadal function, as well as secondary injury.<\/jats:p>","DOI":"10.1155\/2019\/7694503","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T18:32:42Z","timestamp":1549996362000},"page":"1-13","source":"Crossref","is-referenced-by-count":2,"title":["A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls"],"prefix":"10.1155","volume":"2019","author":[{"given":"Janet P.","family":"Niemeier","sequence":"first","affiliation":[{"name":"Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-215X","authenticated-orcid":true,"given":"Paul 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