{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:31:39Z","timestamp":1740177099062,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Province Special Program of Medical Science","award":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"],"award-info":[{"award-number":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"]}]},{"name":"Program of Key Talents of Medical Science in Jiangsu Province","award":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"],"award-info":[{"award-number":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"]}]},{"name":"Suzhou Municipal Application Basic Research Project","award":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"],"award-info":[{"award-number":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"]}]},{"name":"Clinical Key Speciality Project of China","award":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"],"award-info":[{"award-number":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"]}]},{"name":"Clinical Medicine Center of Suzhou","award":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"],"award-info":[{"award-number":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"]}]},{"name":"Suzhou Key Laboratory for Respiratory Medicine","award":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"],"award-info":[{"award-number":["BE2016672","QNRC2016745","SYS201530","SZZX201502","SZS201617"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2019,5,12]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Self-expandable metallic (SEM) airway stents are an important approach to malignant central airway obstruction (CAO). SEM airway stent insertions are usually performed under fluoroscopic guidance over a guide wire placed through a flexible bronchoscope often resulting in a longer procedure time and exposure to radiation. In this pilot study, we designed a novel delivery system of the through-the-scope (TTS) SEM airway stent insertion and observed its feasibility. <jats:italic>Methods<\/jats:italic>. From Jan 2015 to Sept 2016, 25 consecutive patients with inoperable malignant CAO were enrolled requiring airway stent implantation. All patients were followed up to death or at least 6\u2009months. <jats:italic>Results<\/jats:italic>. 36 TTS stents were inserted into 25 patients using a flexible bronchoscope under general anesthesia or local anesthesia. All stents were successfully deployed directly through the working channel (2.8\u2009mm diameter) of the flexible bronchoscope in 91.7% (33\/36) of the subjects. The mMRC score and stenosis grade improved significantly after stent implantation. The common stent-related complications were secretion retention (25%, 9\/36), development of granulation tissue (13.9%, 5\/36), tumor in-growth (13.9%, 5\/36), and hemoptysis (8.3%, 3\/36). The 6-month overall survival (OS) was 44% (11\/25). <jats:italic>Conclusion<\/jats:italic>. The novel TTS stent release system was an effective and safe approach in malignant central airway obstruction.<\/jats:p>","DOI":"10.1155\/2019\/7828526","type":"journal-article","created":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:31:01Z","timestamp":1557689461000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["A Pilot Study of a Novel through-the-Scope Self-Expandable Metallic Airway Stents Delivery System in Malignant Central Airway Obstruction"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jun-hong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-2974","authenticated-orcid":true,"given":"Da-xiong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-guo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3334-8383","authenticated-orcid":true,"given":"Yan-bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-yu","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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