{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:40:33Z","timestamp":1791726033214,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:00:00Z","timestamp":1551571200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interdisciplinary Perspectives on Infectious Diseases"],"published-print":{"date-parts":[[2019,3,3]]},"abstract":"<jats:p><jats:italic>Enterococcus<\/jats:italic> is a commensal in the intestine and is now emerging as a drug-resistant pathogen. It produces different virulence factors.<jats:italic> Enterococcus<\/jats:italic> surface protein (esp) is a virulence factor that helps in the adhesion, but its role in biofilm formation is still contradictory. Moreover, in many bacterial species, strong biofilm producer exhibits multidrug resistance. Hence, this study is done to know the antimicrobial susceptibility pattern of<jats:italic> Enterococcus<\/jats:italic> spp. and to correlate the drug resistance with biofilm production and<jats:italic> esp<\/jats:italic> gene. Enterococcal isolates were collected from various clinical specimens. Antibiotic susceptibility testing was done by disc diffusion, and biofilm production was performed by microtiter plate method. PCR was performed for detection of<jats:italic> esp <\/jats:italic>gene. Two<jats:italic> E. faecium<\/jats:italic> strains resistant to vancomycin and high-level aminoglycoside (HLAR) were non-biofilm-producers and did not harbor<jats:italic> esp<\/jats:italic> gene. However, other biofilm-producing<jats:italic> E. faecium<\/jats:italic> harbored<jats:italic> esp<\/jats:italic> gene, and this association was found to be statistically significant (p=0.024). It was observed that there was no significant association between biofilm formation and presence of<jats:italic> esp<\/jats:italic> gene in<jats:italic> E. faecalis. <\/jats:italic>Moreover, a significant correlation was not found between drug resistance and biofilm production in both<jats:italic> Enterococcus<\/jats:italic> species. Thus, biofilm formation is not always associated with the presence or absence of<jats:italic> esp<\/jats:italic> gene and or drug resistance in<jats:italic> Enterococcus<\/jats:italic> spp.<\/jats:p>","DOI":"10.1155\/2019\/7854968","type":"journal-article","created":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T18:35:13Z","timestamp":1551638113000},"page":"1-6","source":"Crossref","is-referenced-by-count":40,"title":["Antibiotic Susceptibility Pattern and Biofilm Formation in Clinical Isolates of<i> Enterococcus<\/i> spp."],"prefix":"10.1155","volume":"2019","author":[{"given":"Sridevi","family":"Shridhar","sequence":"first","affiliation":[{"name":"Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-0663","authenticated-orcid":true,"given":"Biranthabail","family":"Dhanashree","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"pp. 1294-1298, 2006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1381.1999.99241.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1086\/501795"},{"key":"4","first-page":"1565","volume":"3","year":"2016","journal-title":"International Journal of Contemporary Medical Research"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.6.1173"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2012\/4560.2539"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1086\/320185"},{"key":"8","first-page":"25","volume":"2","year":"2012","journal-title":"National Journal of Medical Research"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.108721"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01918-1"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.6244"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.10.2675-2679.2000"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3658-3663.2004"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47331-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/aem.67.10.4538-4545.2001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.55437"},{"key":"17","year":"1996"},{"key":"18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","volume":"45","year":"1966","journal-title":"American Journal of Clinical Pathology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.120375"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2016.503.075"},{"issue":"5","key":"22","first-page":"365","volume":"5","year":"2011","journal-title":"The Journal of Infection in Developing Countries"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.93032"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2014.12.007"},{"key":"25","first-page":"389","year":"2011","journal-title":"National Journal of Medical Research"},{"issue":"4","key":"26","first-page":"962","volume":"36","year":"2005","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"27","first-page":"e23349","volume":"8","year":"2015","journal-title":"Jundishapur Journal of Microbiology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.956092"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.9790\/0853-1504093337"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801509010014"}],"container-title":["Interdisciplinary Perspectives on Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ipid\/2019\/7854968.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ipid\/2019\/7854968.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ipid\/2019\/7854968.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T18:35:15Z","timestamp":1551638115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ipid\/2019\/7854968\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,3]]},"references-count":29,"alternative-id":["7854968","7854968"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7854968","relation":{},"ISSN":["1687-708X","1687-7098"],"issn-type":[{"value":"1687-708X","type":"print"},{"value":"1687-7098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,3]]}}}