{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:46:43Z","timestamp":1785365203918,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,1,31]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disorder of the hematopoietic stem cells which is often underdiagnosed. Its incidence is about 5 cases per million inhabitants in a year, and currently, there are only 1610 patients in the International PNH Registry. In this report, we describe a case of PNH in southwestern Uganda. <jats:italic>Case Presentation.<\/jats:italic> A 34-year-old man, subsistence farmer, with a history of multiple prior presentations with anemia, jaundice, and dark-colored urine requiring blood transfusions presented to us again in July 2018 with a week\u2019s history of palpitations, dizziness, and dark-colored urine. Investigations done suggested a direct antiglobulin test- (DAT-) negative hemolytic anemia, and subsequently, flow cytometry showed a large clone of PNH. He received many blood transfusions and hematinics on several occasions during the course of his admissions. <jats:italic>Conclusions<\/jats:italic>. Our report showed diagnostic and treatment challenges of PNH in health resource-limited setting.<\/jats:p>","DOI":"10.1155\/2019\/7897509","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T18:30:40Z","timestamp":1548959440000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8697-8979","authenticated-orcid":true,"given":"Boniface Amanee Elias","family":"Lumori","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mbarara University of Science and Technology (MUST), Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Muyanja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mbarara University of Science and Technology (MUST), Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0377-1237(17)31033-x"},{"key":"2","first-page":"595","volume-title":"Hemolytic anemia","year":"2011"},{"key":"3","year":"2015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3513"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1086\/319743"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/363278"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-522128"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000084394.37044.e2"},{"issue":"3","key":"9","first-page":"340","volume":"33","year":"2006","journal-title":"Texas Heart Institute Journal"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.hgmx.2015.07.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-008-0111-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.093161"},{"issue":"13","key":"13","first-page":"351","volume":"43","year":"1969","journal-title":"South African Medical Journal"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2011.00262.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1056\/nejm193712022172307"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1717"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa061648"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)60001-5"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.062828"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/7897509.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/7897509.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/7897509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T18:30:41Z","timestamp":1548959441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/7897509\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,31]]},"references-count":19,"alternative-id":["7897509","7897509"],"URL":"https:\/\/doi.org\/10.1155\/2019\/7897509","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,31]]}}}