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The pigs were divided into control, LPS, LPS+dexamethasone (DEX), LPS+RSG, and LPS+DEX+RSG groups. Their hearing was screened by auditory brainstem response measurement. Immunofluorescence staining was used to identify the location of MKP-1 in the inner ear. The expression levels of MKP-1 and the related proteins in the inner ear were detected using western blotting. The morphological changes in the cochlea were observed via hematoxylin-eosin staining. Severe hearing loss was observed in the LPS group, as opposed to the protection from hearing loss observed in the LPS+DEX+RSG group. A positive correlation was observed between MKP-1 expression levels and protection from hearing loss. RSG and DEX synergistically influenced inner ear inflammation. In conclusion, resistance of LPS-induced SSHL guinea pig models to glucocorticoids may result from impaired MKP-1 function in inner ear tissues, induced by glucocorticoids, impairing the inhibition of inflammation. Our findings present novel targets to develop potential therapeutics to treat inflammatory diseases of the inner ear.<\/jats:p>","DOI":"10.1155\/2019\/7915730","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T20:52:10Z","timestamp":1557867130000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["Rosiglitazone Improves Glucocorticoid Resistance in a Sudden Sensorineural Hearing Loss by Promoting MAP Kinase Phosphatase-1 Expression"],"prefix":"10.1155","volume":"2019","author":[{"given":"Liang","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, No. 600, Yishan Road, Xuhui District, 200233 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated 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