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Drug-induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms (DIHS\/DRESS) is a severe adverse reaction caused by specific drugs. However, little information is available about sequelae following DIHS\/DRESS resolution from an endocrinologist\u2019s perspective. This study aimed to investigate the endocrine sequelae following DIHS\/DRESS, from clinical feature to etiology.<jats:italic>Methods<\/jats:italic>. We retrospectively analyzed the patients diagnosed with DIHS\/DRESS in Peking Union Medical College Hospital (PUMCH) during the period of 1 January 2012 to 31 December 2017, and those who developed endocrine disorders after DIHS\/DRESS were further examined. We also reviewed the literature, from 1 January 2000 to 31 December 2017, on involvement of endocrine glands in DIHS\/DRESS patients.<jats:italic>Results<\/jats:italic>. Three patients developed both autoimmune thyroid disease (AITD) and type 1 diabetes (T1DM)\/fulminant type 1 diabetes (FT1DM) of the 45 patients. Seven cases involving more than two endocrine glands were reported in the literature. Our results indicated that DIHS\/DRESS is a potential etiological factor of autoimmune polyendocrine syndrome (APS), especially APS III.<jats:italic>Conclusions<\/jats:italic>. Patients require careful long-term follow-up after DIHS\/DRESS. Involvement of endocrine glands, especially FT1DM, should always be monitored in patients with a history of DIHS\/DRESS. This study indicated that DIHS\/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS.<\/jats:p>","DOI":"10.1155\/2019\/7959615","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T23:30:48Z","timestamp":1570145448000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS\/DRESS"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7808-5361","authenticated-orcid":true,"given":"Mingqun","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, 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