{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:03:32Z","timestamp":1766466212198,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:p>Dedifferentiated liposarcomas most commonly arise in the retroperitoneum, accounting for 10% of liposarcomas. Heterologous differentiation occurs in 5-10% of dedifferentiated liposarcomas; however, divergent osteosarcomatous differentiation is rare. We report a rare case of initial presentation of dedifferentiated liposarcoma with osteosarcomatous component as a colonic mass in a 72-year-old man. The tumor is mainly composed of bony trabeculae with intervening highly atypical cells and adjacent high-grade mesenchymal nonlipogenic tumor, as well as areas of well-differentiated liposarcoma. Immunohistochemical studies showed diffuse positivity for SATB2 in the atypical cells and fluorescence in situ hybridization revealed high-level amplification of MDM2 gene, supporting the diagnosis of well-differentiated and dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation.<\/jats:p>","DOI":"10.1155\/2019\/8025103","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T19:31:05Z","timestamp":1563219065000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass"],"prefix":"10.1155","volume":"2019","author":[{"given":"Jeenal","family":"Gordhandas","sequence":"first","affiliation":[{"name":"Department of Pathology, University of California San Diego, La Jolla, San Diego, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California San Diego, La Jolla, San Diego, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0825-8674","authenticated-orcid":true,"given":"Ann M. 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