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Currently, the enriched distribution and localization within nociceptors of the selective channel blockers and the critical role played by sodium channels in neuronal excitability nominate isoforms as specific targets to generate innovative compounds. In the present report, we verified the hypothesis that coadministration of Protoxin-II, a selective sodium channel inhibitor, and trace elements has direct and improved antinociceptive effects. Groups of seven Wistar rats were treated intracerebroventricularly with a combination of MgCl<jats:sub>2<\/jats:sub>, CdCl<jats:sub>2<\/jats:sub>, and ZnCl<jats:sub>2<\/jats:sub>and Protoxin-II, respectively, and with Protoxin-II alone (positive) or saline (negative) for controls. Evaluations were performed by nociception assay. Coadministration of these drugs caused an increase in the maximum possible effect of up to 40% as compared with the control groups. Our findings indicate that selective channel blockers continue to be an important nociception target and that the use of trace elements may provide simple but effective means of control over sodium channel blockers\u2019 risks, potentially lowering the necessary analgesic doses, thus improving the efficacy and safety profile.<\/jats:p>","DOI":"10.1155\/2019\/8057803","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T23:30:42Z","timestamp":1577575842000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["Intracerebroventricular Coadministration of Protoxin-II and Trace Elements in Rats Enhances the Analgesic Effect of the 1.7 Voltage-Gate Sodium Channel Blocker"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-9628","authenticated-orcid":true,"given":"Gabriela-Dumitrita","family":"Stanciu","sequence":"first","affiliation":[{"name":"Center for Advanced Research and Development in Experimental Medicine (CEMEX), \u201cGrigore T. 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