{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:16:05Z","timestamp":1790144165185,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Special Research Program for Important Infectious Diseases","award":["2018ZX10715-014-004"],"award-info":[{"award-number":["2018ZX10715-014-004"]}]},{"name":"National Special Research Program for Important Infectious Diseases","award":["2017ZX10202102-002-002"],"award-info":[{"award-number":["2017ZX10202102-002-002"]}]},{"name":"National Special Research Program for Important Infectious Diseases","award":["2018ZX10715-014-004"],"award-info":[{"award-number":["2018ZX10715-014-004"]}]},{"name":"National Special Research Program for Important Infectious Diseases","award":["2017ZX10202102-002-002"],"award-info":[{"award-number":["2017ZX10202102-002-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"Background and Objectives<\/jats:italic>. Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate. To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic potential of echinocandin treatment for AIDS patients with PCP (AIDS-PCP). Methods<\/jats:italic>. The AIDS-PCP patients were analyzed in our retrospective cohort study that were hospitalized in The First Affiliated Hospital of Zhejiang University during 2013\u20132018. The antifungal effects of echinocandins were evaluated in two subgroups that were classified by oxygenation as a proxy for the disease state: Pa<\/mml:mtext>O<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msub>\/<\/mml:mo>Fi<\/mml:mtext>O<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msub>><\/mml:mo>200<\/mml:mn>\u2009<\/mml:mtext>mmHg<\/mml:mtext><\/mml:math> and Pa<\/mml:mtext>O<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msub>\/<\/mml:mo>Fi<\/mml:mtext>O<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msub>\u2264<\/mml:mo>200<\/mml:mn>\u2009<\/mml:mtext>mmHg<\/mml:mtext><\/mml:math>. Intergroup comparisons and survival curves were used to evaluate the effectiveness of the two AIDS-PCP treatment regimens. Results<\/jats:italic>. During the follow-up, 182 AIDS-PCP patients were diagnosed and analyzed in the study. After excluding 55 patients with other superinfections and five patients that were treated with HAART, the remaining 122 patients were enrolled in the study. The group treated with echinocandins combined with trimethoprim-sulfamethoxazole (TMP-SMZ) and clindamycin exhibited a lower mortality rate (9.62%, 5\/52) than did the group with TMP-SMZ and clindamycin treatment (20%, 14\/70). For AIDS-PCP patients in the Pa<\/mml:mtext>O<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msub>\/<\/mml:mo>Fi<\/mml:mtext>O<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msub>><\/mml:mo>200<\/mml:mn>\u2009<\/mml:mtext>mmHg<\/mml:mtext><\/mml:math> subgroup, treatment with echinocandins combined with TMP-SMZ and clindamycin significantly reduced their mortality rate (4.44% (2\/45) vs. 18.18% (10\/55), P<\/mml:mi>=<\/mml:mo>0.035<\/mml:mn><\/mml:math>). Conclusion<\/jats:italic>. The results of this study indicate that treatment with echinocandins in combination with the standard TMP-SMZ and clindamycin regimen can improve the prognosis and reduce the mortality rate in patients with mild to moderate AIDS-PCP disease.<\/jats:p>","DOI":"10.1155\/2019\/8105075","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T09:07:08Z","timestamp":1575277628000},"page":"1-5","source":"Crossref","is-referenced-by-count":16,"title":["A Pilot Study of Echinocandin Combination with Trimethoprim\/Sulfamethoxazole and Clindamycin for the Treatment of AIDS Patients with Pneumocystis Pneumonia"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-2555","authenticated-orcid":true,"given":"Mengyan","family":"Wang","sequence":"first","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Xixi Hospital of Hangzhou, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanjing","family":"Lang","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiqin","family":"Hu","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzheng","family":"Guo","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Tao","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-7193","authenticated-orcid":true,"given":"Xiaotian","family":"Dong","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, 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