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Traditional Chinese medicine (TCM) has been widely applied in chronic hepatitis B (CHB) supplementary treatment in China. Kidney yang deficiency syndrome (KYDS), one of the most common TCM syndromes of CHB, is more likely to progress to liver cirrhosis or hepatocellular carcinoma than other syndromes. Polymorphisms in the human leucocyte antigen- (HLA-) <jats:italic>DQB1<\/jats:italic> and <jats:italic>-DRB1<\/jats:italic> genes were reported to be associated with hepatitis B virus infection outcomes. Here, we investigated whether <jats:italic>HLA-DQB1<\/jats:italic> and <jats:italic>HLA-DRB1<\/jats:italic> are associated with the classification of CHB TCM syndromes. <jats:italic>Methods<\/jats:italic>. We genotyped <jats:italic>HLA-DQB1<\/jats:italic> and <jats:italic>HLA-DRB1<\/jats:italic> alleles in a total of 105 subjects, including 74 CHB patients (28 KYDS and 46 non-KYDS) and 31 healthy individuals from Sichuan Province of Southwest China, by polymerase chain reaction sequence-based typing (PCR-SBT). Moreover, a meta-analysis was carried out for further verification. <jats:italic>Results<\/jats:italic>. The proportion of patients with high HBV DNA load (\u22652000\u2009IU\/ml) in the KYDS group is higher than that in the non-KYDS group (60.70% [17\/28] vs. 28.30% [13\/46]); <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>). The frequencies of <jats:italic>HLA-DQB1<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>\u2217<\/mml:mi><\/mml:math><jats:italic>02<\/jats:italic>:<jats:italic>01<\/jats:italic> (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:mrow><\/mml:math>) and <jats:italic>HLA-DRB1<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>\u2217<\/mml:mi><\/mml:math><jats:italic>03<\/jats:italic>:<jats:italic>01<\/jats:italic> (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:mrow><\/mml:math>) in the KYDS group were significantly increased compared to the non-KYDS group. The gene test and meta-analysis showed that <jats:italic>HLA-DRB1<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>\u2217<\/mml:mi><\/mml:math><jats:italic>08<\/jats:italic>:<jats:italic>03<\/jats:italic> confers susceptibility to CHB (odds ratio\u2009=\u20091.57). <jats:italic>Conclusion<\/jats:italic>. We found an association between <jats:italic>HLA-DRB1<\/jats:italic>\/<jats:italic>DQB1<\/jats:italic> polymorphisms and KYDS of CHB. Moreover, KYDS patients of CHB are characteristic with high HBV DNA loads. These findings help to reveal the biological mechanism of KYDS in high risk of CHB progression and suggest a potential prognostic value for disease outcome evaluation.<\/jats:p>","DOI":"10.1155\/2019\/8146937","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T18:30:42Z","timestamp":1574361042000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["<i>HLA-DQB1<\/i>\/<i>DRB1<\/i> Alleles Associate with Traditional Chinese Medicine Syndrome of Chronic Hepatitis B: A Potential Predictor of Progression"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7898-9224","authenticated-orcid":true,"given":"Xiyang","family":"Liu","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu 610075, 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