{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:26:28Z","timestamp":1774682788643,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2019,6,11]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Takayasu\u2019s arteritis with comorbid chronic recurrent multifocal osteomyelitis and ulcerative colitis is rare in the pediatric population. Treatment with anti-TNF alpha agents such as infliximab has been a successful treatment strategy in adults and can be used effectively in the pediatric population. <jats:italic>Case Presentation.<\/jats:italic> We present the case of a 15-year-old Caucasian girl with a history of chronic recurrent multifocal osteomyelitis and ulcerative colitis presenting with hypertensive emergency secondary to Takayasu\u2019s arteritis with middle aortic syndrome. She was treated with corticosteroids and methotrexate and ultimately required infliximab infusions of 15\u2009mg\/kg every 4\u2009weeks to successfully control her symptoms and normalize her inflammatory markers. <jats:italic>Conclusions<\/jats:italic>. In this case, we discuss the use of infliximab in an adolescent patient with chronic recurrent multifocal osteomyelitis, ulcerative colitis, and Takayasu\u2019s arteritis. The significance of this case is determined by the unique occurrence of all three conditions in a pediatric patient, the important consideration of vasculitis in the differential of a pediatric patient presenting with hypertensive emergency, the need for vigilance for detecting diagnostic clues, signs, and symptoms, knowledge of disease associations when evaluating a patient with a predisposition for autoinflammatory conditions, and the use of increasing doses of infliximab to control symptoms.<\/jats:p>","DOI":"10.1155\/2019\/8157969","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T19:31:00Z","timestamp":1560281460000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["A Case Report of Takayasu\u2019s Arteritis and Ulcerative Colitis in a Pediatric Patient with Chronic Recurrent Multifocal Osteomyelitis Successfully Treated with Infliximab: Diagnostic Clues in Disease Associations and Immune Dysregulation"],"prefix":"10.1155","volume":"2019","author":[{"given":"Viveka Clare","family":"De Guerra","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Oishei Children\u2019s Hospital, 1001 Main Street, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humaira","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Western New York Pediatric Gastroenterology, 166 Washington Avenue, Batavia, NY 14020, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bree","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Oishei Children\u2019s Hospital, 1001 Main Street, Buffalo, NY 14203, USA"},{"name":"Department of Pediatric Critical Care, University at Buffalo, Oishei Children\u2019s Hospital, 1001 Main Street, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rula","family":"Balluz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Oishei Children\u2019s Hospital, 1001 Main Street, Buffalo, NY 14203, USA"},{"name":"Department of Pediatric Cardiology, University at Buffalo, Oishei Children\u2019s Hospital, 1001 Main Street, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Boston Children\u2019s Hospital, 300 Longwood Ave, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Center for Midaortic Syndrome and Renovascular Hypertension, Boston Children\u2019s Hospital, 300 Longwood Ave, Boston, MA 02115, 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