{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:48:27Z","timestamp":1790113707957,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T00:00:00Z","timestamp":1555200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Cell-KGMU"},{"name":"Research Cell, King George\u2019s Medical University Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,4,14]]},"abstract":"<jats:p>Retrospective analysis has already shown correlation between severe Chronic Periodontitis (CP) cases with human papiloma virus (HPV). Hence, we aimed to explore deep-seated infected granulation tissue removed during periodontal flap surgery procedures for residential bacterial species between HPV+ and HVP- CP cases, which may serve as good predisposition marker for oral cancer. All CP-granulation samples showed the prominence of<jats:italic>Firmicutes, Proteobacteria<\/jats:italic>, and<jats:italic>Bacteroidetes<\/jats:italic>phyla with an abundance of gram negative anaerobes, except<jats:italic>Streptococcus<\/jats:italic>. In Beta diversity nonmetric multidimensional scaling plot, the random distribution of species was observed between HPV+ and HPV- CP granulation-samples. However, an abundance of<jats:italic>Capnocytophaga ochracea<\/jats:italic>was observed in HPV+ CP samples (p&lt;0.05), while<jats:italic>Porphyromonas endodontalis<\/jats:italic>,<jats:italic>Macellibacteroides fermentas<\/jats:italic>,<jats:italic>Treponema phagedenis<\/jats:italic>, and<jats:italic>Campylobacter rectus<\/jats:italic>species were highly abundant in HPV- CP samples (p&lt;0.05). The differential species richness leads altered functions related to mismatch-repair and nucleotide excision-repair and cytoskeleton-proteins. Hence, differential abundance of gram negative bacterial species between HPV+ and HPV- granulation-samples under anaerobic conditions may release virulence factors which may alter pathways favouring carcinogenesis. Hence, these species may serve as good predisposition marker for oral-cancer.<\/jats:p>","DOI":"10.1155\/2019\/8163591","type":"journal-article","created":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T23:31:36Z","timestamp":1555284696000},"page":"1-12","source":"Crossref","is-referenced-by-count":17,"title":["Dysbiosis and Variation in Predicted Functions of the Granulation Tissue Microbiome in HPV Positive and Negative Severe Chronic Periodontitis"],"prefix":"10.1155","volume":"2019","author":[{"given":"Rebecca","family":"Chowdhry","sequence":"first","affiliation":[{"name":"Department of Periodontology, King George\u2019s Medical University, Lucknow 226 003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-655X","authenticated-orcid":true,"given":"Neetu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Center for Advance Research, King George\u2019s Medical University, 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