{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:35:06Z","timestamp":1747190106591,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2019,6,19]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Erythema nodosum leprosum (ENL) is a type of lepra reaction treated with corticosteroids and thalidomide, but this association increases the risk of deep venous thrombosis (DVT).<jats:italic>Objective<\/jats:italic>. To report cases of ENL with DVT in the use of thalidomide\/corticosteroid associated.<jats:italic>Methodology<\/jats:italic>. The study was conducted between December 2015 and December 2016 at the Eduardo de Menezes Hospital (HEM-FHEMIG).<jats:italic>Results<\/jats:italic>. A clinical case series of 16 patients, eight from HEM-FHEMIG and eight from the literature. DVT occurred on 4 continents, mainly in adults and men. All patients were multibacillary; four people had pulmonary embolism (PE); there were 11 unilateral and five bilateral DVT cases; 12 cases were proximal, two distal, and two unspecified. Pharmacological thromboprophylaxis was used on two individuals. Outcome after DVT, 14 patients improved, one had sequelae, and one died.<jats:italic>Discussion<\/jats:italic>. DVT increased in association with thalidomide\/corticosteroid in multiple myeloma, but this complication is poorly described in ENL. In proximal DVT, there was a greater risk of PE and sequelae venous insufficiency. After DVT, start anticoagulation. ASA 100mg\/day as prophylaxis for DVT in case of this drug association in ENL is recommended.<jats:italic>Conclusion<\/jats:italic>. The article illustrates the incidence increase of DVT because of the thalidomide\/corticosteroid combination in ENL. When this association is necessary, use ASA 100mg\/day as prophylaxis.<\/jats:p>","DOI":"10.1155\/2019\/8181507","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T23:31:57Z","timestamp":1560987117000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-6211","authenticated-orcid":true,"given":"Luiz Alberto Bomjardim","family":"P\u00f4rto","sequence":"first","affiliation":[{"name":"Dermatology Service Eduardo de Menezes Hospital, FHEMIG, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida de Faria","family":"Grossi","sequence":"additional","affiliation":[{"name":"Secretary of State for Health, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilamar Silva de","family":"Alecrim","sequence":"additional","affiliation":[{"name":"Dermatology Service Eduardo de Menezes Hospital, FHEMIG, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Henrique de Souza Brito","family":"Xavier","sequence":"additional","affiliation":[{"name":"Dermatology Service Alberto Cavalcante Hospital, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico","family":"Paiva e Silva","sequence":"additional","affiliation":[{"name":"Dermatology Service Eduardo de Menezes Hospital, FHEMIG, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia Sathler","family":"Pires","sequence":"additional","affiliation":[{"name":"Dermatology Service Eduardo de Menezes Hospital, FHEMIG, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabianny Sanglard da","family":"Silva","sequence":"additional","affiliation":[{"name":"Dermatology Service Eduardo de Menezes Hospital, FHEMIG, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Lyon","sequence":"additional","affiliation":[{"name":"Dermatology Service Eduardo de Menezes Hospital, FHEMIG, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume":"93, no. 35","year":"2015","key":"1"},{"year":"2017","key":"2"},{"volume":"70","year":"2010","key":"3"},{"year":"2017","key":"4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2011.12.002"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.47276\/lr.79.2.193","volume":"79","year":"2008","journal-title":"Leprosy 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