{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:11:09Z","timestamp":1790475069902,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Construction Project of Health and Family Planning Commission of Baoshan District, Shanghai","award":["BSZK-2018-A01"],"award-info":[{"award-number":["BSZK-2018-A01"]}]},{"name":"Key Construction Project of Health and Family Planning Commission of Baoshan District, Shanghai","award":["20184Y0179"],"award-info":[{"award-number":["20184Y0179"]}]},{"name":"Youth Programs of Shanghai Municipal Commission of Health and Family Planning","award":["BSZK-2018-A01"],"award-info":[{"award-number":["BSZK-2018-A01"]}]},{"name":"Youth Programs of Shanghai Municipal Commission of Health and Family Planning","award":["20184Y0179"],"award-info":[{"award-number":["20184Y0179"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,2,25]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Several studies have investigated the association between Toxoplasma gondii (T. gondii) infection and risk of Parkinson\u2019s disease (PD) with inconsistent results. Clarifying this relation might be useful for better understanding of the risk factors and the relevant mechanisms of PD, thus a meta-analysis was conducted to explore whether exposure to T. gondii is associated with an increased risk of PD.<jats:italic> Methods<\/jats:italic>. We conducted this meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A rigorous literature selection was performed by using the databases of PubMed, Embase, Web of Science, Cochrane Library, and ScienceDirect. Odds ratio (OR) and corresponding 95% confidential interval (CI) were pooled by using fixed-effects models. Sensitivity analysis, publication bias test, and methodological quality assessment of studies were also performed.<jats:italic> Results<\/jats:italic>. Seven studies involving 1086 subjects were included in this meta-analysis. Pooled data by using fixed-effects models suggested both latent infection (OR, 1.17; 95% CI, 0.86 to 1.58;<jats:italic> P<\/jats:italic>=0.314) and acute infection (OR, 1.13; 95% CI, 0.30 to 4.35;<jats:italic> P<\/jats:italic>=0.855) were not associated with PD risk. Stable and robust estimates were confirmed by sensitivity analysis. No publication bias was found by visual inspection of the funnel plot, Begg\u2019s, and Egger\u2019s test.<jats:italic> Conclusions<\/jats:italic>. This meta-analysis does not support any possible association between T. gondii infection and risk of PD. Researches are still warranted to further explore the underlying mechanisms of T. gondii in the pathogenesis of PD and their causal relationship.<\/jats:p>","DOI":"10.1155\/2019\/8186017","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T18:31:21Z","timestamp":1551119481000},"page":"1-8","source":"Crossref","is-referenced-by-count":15,"title":["The Association between Toxoplasma gondii Infection and Risk of Parkinson\u2019s Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2019","author":[{"given":"Zonglei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Sichuan University West China School of Public Health, Chengdu 610041, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzhen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery, Changhai Hospital of Shanghai, Shanghai 200433, 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